ArticleScientific reports2011
Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Leaky and waveguide modes in biperiodic holograms.Scientific reports · 2021Article
- Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies.Pharmacology research & perspectives · 2018Article
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- Discovery of new muscarinic acetylcholine receptor antagonists from Scopolia tangutica.Scientific reports · 2017Article
- Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel.Scientific reports · 2014Article
- Dynamic mass redistribution analysis of endogenous β-adrenergic receptor signaling in neonatal rat cardiac fibroblasts.Pharmacology research & perspectives · 2014Article
- Divergent label-free cell phenotypic pharmacology of ligands at the overexpressed β₂-adrenergic receptors.Scientific reports · 2014Article
- Label-free drug discovery.Frontiers in pharmacology · 2014Review
- Microplate-compatible total internal reflection fluorescence microscopy for receptor pharmacology.Applied physics letters · 2013Article
- Label-free integrative pharmacology on-target of opioid ligands at the opioid receptor family.BMC pharmacology & toxicology · 2013Article
- Approaches for probing allosteric interactions at 7 transmembrane spanning receptors.Progress in molecular biology and translational science · 2013Review
- Aspirin metabolites are GPR35 agonists.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Article
- Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.PloS one · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a label-free integrative pharmacology on-target (iPOT) method to assess the pharmacology of drugs at the β(2)-adrenergic receptor. This method combines dynamic mass redistribution (DMR) assays using an array of probe molecule-hijacked cells with similarity analysis. The whole cell DMR assays track cell system-based, ligand-directed, and kinetics-dependent biased activities of the drugs, and translates their on-target pharmacology into numerical descriptors which are subject to similarity analysis. We demonstrate that the approach establishes an effective link between the label-free pharmacology and in vivo therapeutic indications of drugs.
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