ArticleScientific reports2011
Molecular evolution of HR, a gene that regulates the postnatal cycle of the hair follicle.
Article in Scientific reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Hairless Gene Nonsense Mutations in Alopecia Universalis: A Case Report.Iranian journal of public health · 2021Article
- Ticks, Hair Loss, and Non-Clinging Babies: A Novel Tick-Based Hypothesis for the Evolutionary Divergence of Humans and Chimpanzees.Life (Basel, Switzerland) · 2021Article
- Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson's disease and other neurological disorders.BMC evolutionary biology · 2020Article
- Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene.BMC evolutionary biology · 2019Article
- The Parkinson Disease gene SNCA: Evolutionary and structural insights with pathological implication.Scientific reports · 2016Article
- Comparative genomics using teleost fish helps to systematically identify target gene bodies of functionally defined human enhancers.BMC genomics · 2013Article
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1 author.
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Abstract
Hair is a unique mammalian trait that is absent in all other animal forms. Hairlessness is rare in mammals and humans are exceptional among primates in lacking dense layer of hair covering. HR was the first gene identified to be implicated in hair-cycle regulation. Point mutations in HR lead to congenital human hair loss, which results in the complete loss of body and scalp hairs. HR functions are indispensable for initiation of postnatal hair follicular cycling. This study investigates the phylogenetic history and analyzes the protein evolutionary rate to provide useful insight into the molecular evolution of HR. The data demonstrates an acceleration of HR sequence evolution in human branch and suggests that the ability of HR protein to mediate postnatal hair-cycling has been altered in the course of human evolution. In particular those residues were pinpointed which should be regarded as target of positive Darwinian selection during human evolution.
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