ArticlePediatric reports2011
The coagulopathy in sepsis: significance and implications for treatment.
Article in Pediatric reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study.EBioMedicine · 2020Pooled it
- Neonatal Sepsis-Induced Coagulopathy in the Light of Developmental Hemostasis: Friend or Foe?Medicina (Kaunas, Lithuania) · 2026Review
- A Global Assessment of Coagulation Profile and a Novel Insight into Adamts-13 Implication in Neonatal Sepsis.Biology · 2023Article
- Effect of Phytonadione on Correction of Coagulopathy in Pediatric Patients With Septic Shock.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- The importance of serum LMAN2 level in septic shock and prognosis prediction in sepsis patients.Heliyon · 2022Article
- Correlation between thrombopoietin and inflammatory factors, platelet indices, and thrombosis in patients with sepsis: A retrospective study.World journal of clinical cases · 2022Article
- Association Between Different DVT Prevention Methods and Outcomes of Septic Shock Caused by Intestinal Perforation in China: A Cross-Sectional Study.Frontiers in medicine · 2022Article
- Context-Responsive Anticoagulation Reduces Complications in Pediatric Extracorporeal Membrane Oxygenation.Frontiers in cardiovascular medicine · 2021Article
- Characterization of circulating thrombin in patients with septic shock: a prospective observational study.Journal of thrombosis and thrombolysis · 2020Observational
- Necrotizing Fasciitis: Pillaging the Acute Phase Response.The Journal of bone and joint surgery. American volume · 2020Review
- Article
- Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock.Thrombosis research · 2019Article
- Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models.Frontiers in immunology · 2019Review
- Regional citrate-calcium anticoagulation during polymyxin-B hemoperfusion: A case series.The International journal of artificial organs · 2018Article
- Biomarker Profile of Sepsis-Associated Coagulopathy Using Biochip Assay for Inflammatory Cytokines.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
- To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?Seminars in thrombosis and hemostasis · 2018Review
- Examination of biomarker expressions in sepsis-related DIC patients.International journal of general medicine · 2018Article
- Article
- Prophylaxis and Incidence of Symptomatic Deep Vein Thrombosis in Indian Patients with Sepsis: DETECT-Deep Vein Thrombosis Registry.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2017Article
- A Dormant Microbial Component in the Development of Preeclampsia.Frontiers in medicine · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis related coagulopathy ranges from mild laboratory alterations up to severe disseminated intravascular coagulation (DIC). There is evidence that DIC is involved in the pathogenesis of microvascular dysfunction contributing to organ failure. Additionally, the systemic activation of coagulation, by consuming platelets and coagulation factors, may cause bleeding. Thrombin generation via the tissue factor/factor VIIa route, contemporary depression of antithrombin and protein C anticoagulant systems, as well as impaired fibrin degradation, due to high circulating levels of PAI-1, contribute to enhanced intravascular fibrin deposition. This deranged coagulopathy is an independent predictor of clinical outcome in patients with severe sepsis. Innovative supportive strategies aiming at the inhibition of coagulation activation should comprise inhibition of tissue factor-mediated activation or restoration of physiological anticoagulant pathways, as the administration of recombinant human activated protein C or concentrate. In spite of some promising initial studies, additional trials are needed to define their clinical effectiveness in adults and children with severe sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.