Evidence map›Paper›PMID 22355455›Full record

ArticleViruses2012

Molecular and cellular aspects of rhabdovirus entry.

Aurélie A V Albertini, Eduard Baquero, Anna Ferlin, Yves Gaudin

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 169 citations in OpenAlex.

  1. Review
  2. Article
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  5. Review
  6. Article
  7. Article
  8. Unraveling the complexities of neurotropic virus infection and immune evasion.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  9. Bat Rhabdoviruses: occurrence, detection and challenges in Africa.Tropical animal health and production · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Aurélie A V AlbertiniLaboratoire de Virologie Moléculaire et Structurale, Centre de Recherche de Gif, CNRS (UPR 3296), Avenue de la Terrasse, 91198, Gif sur Yvette Cedex, France. alberti@vms.cnrs-gif.fr
Eduard Baquero
Anna Ferlin
Yves Gaudin
Laboratoire de Virologie Moléculaire et Structurale · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rhabdoviruses enter the cell via the endocytic pathway and subsequently fuse with a cellular membrane within the acidic environment of the endosome. Both receptor recognition and membrane fusion are mediated by a single transmembrane viral glycoprotein (G). Fusion is triggered via a low-pH induced structural rearrangement. G is an atypical fusion protein as there is a pH-dependent equilibrium between its pre- and post-fusion conformations. The elucidation of the atomic structures of these two conformations for the vesicular stomatitis virus (VSV) G has revealed that it is different from the previously characterized class I and class II fusion proteins. In this review, the pre- and post-fusion VSV G structures are presented in detail demonstrating that G combines the features of the class I and class II fusion proteins. In addition to these similarities, these G structures also reveal some particularities that expand our understanding of the working of fusion machineries. Combined with data from recent studies that revealed the cellular aspects of the initial stages of rhabdovirus infection, all these data give an integrated view of the entry pathway of rhabdoviruses into their host cell.

Indexed as

Virus InternalizationAnimalsCrystallography, X-RayEndocytosisEndosomesGenome, ViralHumansHydrogen-Ion ConcentrationMembrane FusionMembrane GlycoproteinsMiceNeuronsProtein ConformationReceptors, VirusRhabdoviridaeRhabdoviridae InfectionsG protein, vesicular stomatitis virusMembrane GlycoproteinsReceptors, VirusViral Envelope ProteinsViral Proteinsendocytosisglycoproteinmembrane fusionrabies virusrhabdovirusvesicular stomatitis virus

Identifiers

PMID22355455
PMCPMC3280520
OpenAlexW2042741698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.