ArticlePloS one2012
Estrogens can disrupt amphibian mating behavior.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- Testosterone and estradiol predict male calling performance, but not performance-related tradeoffs, in competitive signaling environments in Cope's gray treefrogs (Hyla chrysoscelis).Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- Chemical Interference: A Review on Endocrine Disruptors and Reproductive Communication in Amphibians.Ecology and evolution · 2025Review
- Endocrine disruption in teleosts and amphibians is mediated by anthropogenic and natural environmental factors: implications for risk assessment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Independent and synergistic effects of microplastics and endocrine-disrupting chemicals on the reproductive social behavior of fathead minnows (Ecology and evolution · 2024Article
- Nature based solutions for removal of steroid estrogens in wastewater.Frontiers in microbiology · 2024Review
- Review
- 17α-Ethinylestradiol (EE2): concentrations in the environment and methods for wastewater treatment - an update.RSC advances · 2022Review
- Impact of Estrogens Present in Environment on Health and Welfare of Animals.Animals : an open access journal from MDPI · 2021Review
- Coatings of magnetic composites of iron oxide and carbon nitride for photocatalytic water purification.RSC advances · 2021Article
- Monitoring wetland water quality related to livestock grazing in amphibian habitats.Environmental monitoring and assessment · 2021Article
- Thin Coatings of α- and β-BiChemistryOpen · 2020Article
- Article
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- Considering Conversion: The Aftermath of Oral Contraceptives.The Linacre quarterly · 2018Article
- Effects of contaminants of emerging concern on Myzus persicae (Sulzer, Hemiptera: Aphididae) biology and on their host plant, Capsicum annuum.Environmental monitoring and assessment · 2018Article
- Article
- Contaminants of emerging concern affectProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effects of contaminants of emerging concern on Megaselia scalaris (Lowe, Diptera: Phoridae) and its microbial community.Scientific reports · 2017Article
- Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Sex reversal assessments reveal different vulnerability to endocrine disruption between deeply diverged anuran lineages.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main component of classical contraceptives, 17α-ethinylestradiol (EE2), has high estrogenic activity even at environmentally relevant concentrations. Although estrogenic endocrine disrupting compounds are assumed to contribute to the worldwide decline of amphibian populations by adverse effects on sexual differentiation, evidence for EE2 affecting amphibian mating behaviour is lacking. In this study, we demonstrate that EE2 exposure at five different concentrations (0.296 ng/L, 2.96 ng/L, 29.64 ng/L, 2.96 µg/L and 296.4 µg/L) can disrupt the mating behavior of adult male Xenopus laevis. EE2 exposure at all concentrations lowered male sexual arousal, indicated by decreased proportions of advertisement calls and increased proportions of the call type rasping, which characterizes a sexually unaroused state of a male. Additionally, EE2 at all tested concentrations affected temporal and spectral parameters of the advertisement calls, respectively. The classical and highly sensitive biomarker vitellogenin, on the other hand, was only induced at concentrations equal or higher than 2.96 µg/L. If kept under control conditions after a 96 h EE2 exposure (2.96 µg/L), alterations of male advertisement calls vanish gradually within 6 weeks and result in a lower sexual attractiveness of EE2 exposed males toward females as demonstrated by female choice experiments. These findings indicate that exposure to environmentally relevant EE2 concentrations can directly disrupt male mate calling behavior of X. laevis and can indirectly affect the mating behavior of females. The results suggest the possibility that EE2 exposure could reduce the reproductive success of EE2 exposed animals and these effects might contribute to the global problem of amphibian decline.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.