ArticlePloS one2012
A genome wide association scan of bovine tuberculosis susceptibility in Holstein-Friesian dairy cattle.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- Prevalence of tuberculosis in bovines in Pakistan during 2000-2024: a systematic review and meta-analysis.Frontiers in veterinary science · 2025Pooled it
- Bovine tuberculosis in Ethiopia: A systematic review and meta-analysis.Preventive veterinary medicine · 2017Pooled it
- Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.PloS one · 2015Pooled it
- Genome-wide association analysis revealed novel candidate genes for body measurement traits in indigenous Gudali and crossbred Simgud in Cameroon.BMC genomics · 2025Article
- Integrative genomics sheds light on the immunogenetics of tuberculosis in cattle.Communications biology · 2025Article
- Epidemiological Trend Analysis of Bovine Tuberculosis and Its Public Health Impact in Ethiopia.Journal of tropical medicine · 2025Review
- Genome-Wide Association Study Reveals Quantitative Trait Loci and Candidate Genes Associated with High Interferon-gamma Production in Holstein Cattle Naturally Infected withInternational journal of molecular sciences · 2024Article
- The effects of case/control ratio and sample size on genome-wide association studies: A simulation study.Veterinary medicine and science · 2024Article
- Exploring the association betweenArchives animal breeding · 2024Article
- Selective breeding can contribute to bovine tuberculosis control and eradication.Irish veterinary journal · 2023Review
- Deletion in KARLN intron 5 and predictive relationship with bovine tuberculosis and brucellosis infection phenotype.Veterinary research communications · 2023Article
- MIDESP: Mutual Information-Based Detection of Epistatic SNP Pairs for Qualitative and Quantitative Phenotypes.Biology · 2021Article
- Integrative genomics of the mammalian alveolar macrophage response to intracellular mycobacteria.BMC genomics · 2021Article
- Host Serum Proteins as Potential Biomarkers of Bovine Tuberculosis Resistance Phenotype.Frontiers in veterinary science · 2021Article
- Article
- Genome-wide association studies for methane emission and ruminal volatile fatty acids using Holstein cattle sequence data.BMC genetics · 2020Article
- Analysis of Genetic Variation in the BovineFrontiers in microbiology · 2020Article
- Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis.Frontiers in genetics · 2020Article
- Article
- Genome-Wide Association Study of Growth and Body-Shape-Related Traits in Large Yellow Croaker (Larimichthys crocea) Using ddRAD Sequencing.Marine biotechnology (New York, N.Y.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and dissection of this may enlighten on the wider biology of host response to tuberculosis. However, a binary phenotype of presence/absence of infection presents a noisy signal for genomewide association study. METHODOLOGY/PRINCIPAL
findingsWe calculated a composite phenotype of genetic merit for TB susceptibility based on disease incidence in daughters of elite sires used for artificial insemination in the Irish dairy herd. This robust measure was compared with 44,426 SNP genotypes in the most informative 307 subjects in a genome wide association analysis. Three SNPs in a 65 kb genomic region on BTA 22 were associated (i.e. p<10(-5), peaking at position 59588069, p = 4.02×10(-6)) with tuberculosis susceptibility. CONCLUSIONS/SIGNIFICANCE: A genomic region on BTA 22 was suggestively associated with tuberculosis susceptibility; it contains the taurine transporter gene SLC6A6, or TauT, which is known to function in the immune system but has not previously been investigated for its role in tuberculosis infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.