ArticleGenome biology and evolution2012
Population genomics and phylogeography of an Australian dairy factory derived lytic bacteriophage.
Article in Genome biology and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Diversity and functional characterization of HNH endonucleases encoded by lactococcalMicrobial genomics · 2025Article
- Distinct shifts in bacteriophage diversity and abundance during various stages of Gouda-type cheese production.Applied and environmental microbiology · 2025Article
- Longitudinal Study ofApplied and environmental microbiology · 2023Article
- Article
- A comparative genomics approach for identifying host-range determinants in Streptococcus thermophilus bacteriophages.Scientific reports · 2019Article
- Molecular, physiological and phylogenetic traits of Lactococcus 936-type phages from distinct dairy environments.Scientific reports · 2018Article
- The Tape Measure Protein Is Involved in the Heat Stability of Lactococcus lactis Phages.Applied and environmental microbiology · 2018Article
- Metagenomic Analysis of Dairy Bacteriophages: Extraction Method and Pilot Study on Whey Samples Derived from Using Undefined and Defined Mesophilic Starter Cultures.Applied and environmental microbiology · 2017Article
- The Baseplate of Lactobacillus delbrueckii Bacteriophage Ld17 Harbors a Glycerophosphodiesterase.The Journal of biological chemistry · 2016Article
- Comparative genomics and functional analysis of the 936 group of lactococcal Siphoviridae phages.Scientific reports · 2016Article
- Article
- Methyltransferases acquired by lactococcal 936-type phage provide protection against restriction endonuclease activity.BMC genomics · 2014Article
- Progress in lactic acid bacterial phage research.Microbial cell factories · 2014Review
- Article
- Current taxonomy of phages infecting lactic acid bacteria.Frontiers in microbiology · 2014Review
- Structure and functional analysis of the host recognition device of lactococcal phage tuc2009.Journal of virology · 2013Article
- Investigation of the relationship between lactococcal host cell wall polysaccharide genotype and 936 phage receptor binding protein phylogeny.Applied and environmental microbiology · 2013Article
- Complete genome sequence of the 936-type lactococcal bacteriophage CaseusJM1.Genome announcements · 2013Article
- Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit.Acta crystallographica. Section F, Structural biology and crystallization communications · 2013Article
- Review
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we present the full genomic sequences and evolutionary analyses of a serially sampled population of 28 Lactococcus lactis-infecting phage belonging to the 936-like group in Australia. Genome sizes were consistent with previously available genomes ranging in length from 30.9 to 32.1 Kbp and consisted of 55-65 open reading frames. We analyzed their genetic diversity and found that regions of high diversity are correlated with high recombination rate regions (P value = 0.01). Phylogenetic inference showed two major clades that correlate well with known host range. Using the extended Bayesian Skyline model, we found that population size has remained mostly constant through time. Moreover, the dispersion pattern of these genomes is in agreement with human-driven dispersion as suggested by phylogeographic analysis. In addition, selection analysis found evidence of positive selection on codon positions of the Receptor Binding Protein (RBP). Likewise, positively selected sites in the RBP were located within the neck and head region in the crystal structure, both known determinants of host range. Our study demonstrates the utility of phylogenetic methods applied to whole genome data collected from populations of phage for providing insights into applied microbiology.
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