ArticlemBio2012
Comparative genomics of enterococci: variation in Enterococcus faecalis, clade structure in E. faecium, and defining characteristics of E. gallinarum and E. casseliflavus.
Article in mBio, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 209 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
209 citing papers in PubMed, 343 citations in OpenAlex.
- Intra-species competition combats vancomycin-resistant enterococci.Gut microbes · 2026Article
- Article
- Widespread dissemination of the RepA_N-type megaplasmid conferring a carbohydrate utilization advantage in clonal complex 17Microbiology spectrum · 2026Article
- Article
- Draft genome sequences forMicrobiology resource announcements · 2026Article
- Article
- Cross-Sector Antimicrobial Resistance and Virulence inAntibiotics (Basel, Switzerland) · 2026Article
- Molecular Epidemiology, Phenotypic and Genomic Characterization of Multidrug-Resistant Enterococcus Faecium Isolated from Bovine Mastitis in Ningxia, China (2019-2024).Microorganisms · 2026Article
- Article
- Efagins - engineerable agents that evolved independently to target the enterococcal cell wall.bioRxiv : the preprint server for biology · 2026Article
- Biofilm Formation, Virulence Traits, and Antimicrobial Resistance Profiles ofInternational journal of microbiology · 2026Article
- Article
- SEDS glycosyltransferases inmSphere · 2025Article
- Deciphering the Genomic Traits of Multi-Enterocin-ProducingMicroorganisms · 2025Article
- Prolonged exposure to teixobactin generates cross-tolerance to other cell wall-targeting antimicrobials inAntimicrobial agents and chemotherapy · 2025Article
- Draft genome sequences forbioRxiv : the preprint server for biology · 2025Article
- Serine recombinases are conserved genetic markers of antiphage defense systems.bioRxiv : the preprint server for biology · 2025Article
- Hidden diversity inMicrobiology spectrum · 2025Article
- Epidemiology, clinical characteristics, and outcome of enterococcal bloodstream infections in critically ill patients in China: a single-center retrospective 10-year analysis.Microbiology spectrum · 2025Article
- Factors affecting CRISPR-Cas defense against antibiotic resistance plasmids harboured byMicrobiology (Reading, England) · 2025Article
149 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
The enterococci are Gram-positive lactic acid bacteria that inhabit the gastrointestinal tracts of diverse hosts. However, Enterococcus faecium and E. faecalis have emerged as leading causes of multidrug-resistant hospital-acquired infections. The mechanism by which a well-adapted commensal evolved into a hospital pathogen is poorly understood. In this study, we examined high-quality draft genome data for evidence of key events in the evolution of the leading causes of enterococcal infections, including E. faecalis, E. faecium, E. casseliflavus, and E. gallinarum. We characterized two clades within what is currently classified as E. faecium and identified traits characteristic of each, including variation in operons for cell wall carbohydrate and putative capsule biosynthesis. We examined the extent of recombination between the two E. faecium clades and identified two strains with mosaic genomes. We determined the underlying genetics for the defining characteristics of the motile enterococci E. casseliflavus and E. gallinarum. Further, we identified species-specific traits that could be used to advance the detection of medically relevant enterococci and their identification to the species level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.