ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2012
Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Impact of OXTR, COMT, and GRIN2B Polymorphisms on Brain Development in Preterm Infants.Journal of clinical medicine · 2025Article
- Article
- Review
- The inconsistent mediating effect of catecholFrontiers in psychiatry · 2022Article
- Investigation of inflammation related gene polymorphism of the mannose-binding lectin 2 in schizophrenia and bipolar disorder.Neurosciences (Riyadh, Saudi Arabia) · 2021Article
- The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia.Current issues in molecular biology · 2021Article
- Haplotypic and Genotypic Association of Catechol-Frontiers in pharmacology · 2018Article
- Neurobiological background of negative symptoms.European archives of psychiatry and clinical neuroscience · 2015Review
- Gene-sex interactions in schizophrenia: focus on dopamine neurotransmission.Frontiers in behavioral neuroscience · 2014Review
- Association of estrogen receptor alpha gene polymorphism with age at onset, general psychopathology symptoms, and therapeutic effect of schizophrenia.Behavioral and brain functions : BBF · 2013Article
- No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population.Molecular biology reports · 2013Article
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7 authors.
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Abstract
The gene encoding Catechol-O-methyltransferase (COMT), a dopamine catabolic enzyme, has been associated inconsistently with schizophrenia in spite of consistent evidence for dopaminergic dysfunction in the prefrontal cortex (PFC) of schizophrenia. Since one contribution to this inconsistency might be genetic heterogeneity, this study investigated whether the COMT gene was associated with the development and symptoms of schizophrenia in relatively genetically homogeneous Chinese schizophrenic patients. We analyzed two polymorphisms (rs740603 and rs4818) of the COMT gene in a case-control study of 604 Han Chinese (284 patients and 320 controls). The patients' psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). We found no significant differences in the rs740603 and rs4818 genotype and allele distributions between the patient and control groups. Quantitative trait analysis by the UNPHASED program showed that the rs740603 and rs740603(G)-rs4818(G) haplotypes were associated with negative symptoms in the schizophrenic patients, particularly among female patients. Thus, the COMT gene polymorphisms may not contribute to the susceptibility to schizophrenia, but may contribute to the negative symptoms of schizophrenia among Han Chinese.
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