ArticlePsychopharmacology2012
Inter-individual diversity and intra-individual stability of amphetamine-induced sensitization of frequency-modulated 50-kHz vocalization in Sprague-Dawley rats.
Article in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs.Psychopharmacology · 2026Article
- Spatio-temporal mechanisms of consolidation, recall and reconsolidation in reward-related memory trace.Molecular psychiatry · 2025Article
- Amphetamine-induced prolonged disturbances in tissue levels of dopamine and serotonin in the rat brain.Pharmacological reports : PR · 2023Article
- Article
- A Protocol for the Non-invasive Method of Ultrasound Separation During the Sociosexual Vocal-Non-contact Model in Rats.Frontiers in behavioral neuroscience · 2022Article
- Anticipatory 50-kHz Precontact Ultrasonic Vocalizations and Sexual Motivation: Characteristic Pattern of Ultrasound Subtypes in an Individual Analyzed Profile.Frontiers in behavioral neuroscience · 2021Article
- Inter-individual differences in serotonin and glutamate co-transmission reflect differentiation in context-induced conditioned 50-kHz USVs response after morphine withdrawal.Brain structure & function · 2018Article
- Mapping trait-like socio-affective phenotypes in rats through 50-kHz ultrasonic vocalizations.Psychopharmacology · 2018Article
- Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response.Behavioural brain research · 2017Article
- Poor sensitization of 50-kHz vocalization response to amphetamine predicts rat susceptibility to self-administration of the drug.Psychopharmacology · 2016Article
- Novelty response and 50 kHz ultrasonic vocalizations: Differential prediction of locomotor and affective response to amphetamine in Sprague-Dawley rats.Psychopharmacology · 2016Article
- Strain-and context-based 50 kHz ultrasonic vocalizations and anxiety behaviour in the Wistar-Kyoto rat.Journal of biosciences · 2015Article
- κ-opioid receptor as a key mediator in the regulation of appetitive 50-kHz ultrasonic vocalizations.Psychopharmacology · 2015Article
- Critical involvement of 5-HT2C receptor function in amphetamine-induced 50-kHz ultrasonic vocalizations in rats.Psychopharmacology · 2015Article
- Environmental and Pharmacological Modulation of Amphetamine- Induced 50-kHz Ultrasonic Vocalizations in Rats.Current neuropharmacology · 2015Review
- Ultrasonic Vocalizations as a Measure of Affect in Preclinical Models of Drug Abuse: A Review of Current Findings.Current neuropharmacology · 2015Review
- Rat ultrasonic vocalizations demonstrate that the motivation to contextually reinstate cocaine-seeking behavior does not necessarily involve a hedonic response.Addiction biology · 2014Article
- Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats.Behavioural brain research · 2014Article
- Ultrasonic vocalizations: evidence for an affective opponent process during cocaine self-administration.Psychopharmacology · 2014Article
- The covariation of acoustic features of infant cries and autonomic state.Physiology & behavior · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationalePropensity for drug dependence shows great diversity that is related to intrinsic neurobiological factors. This diversity is important both for the understanding of these traits and for the development of therapies.
objectivesThe goals of the study were (1) to define, using ultrasonic vocalization characteristics, inter-individual differences in rats' propensity for sensitization to amphetamine, (2) to test whether possible resistance to this effect could be overcome with repetitive treatment, and (3) to seek useful predictors of the propensity.
methodsRats were subject to tests meant to characterize their anxiety, pain sensitivity, and responses to novelty and natural rewards. Then they were subject to the so-called two-injection protocol of sensitization (using amphetamine) followed by 2 weeks of daily amphetamine treatment, 2-week withdrawal, and final amphetamine challenge. The development and outcome of sensitization were monitored by measuring 50-kHz vocalization.
resultsThe two-injection protocol yielded three patterns of changes in the frequency-modulated 50-kHz vocalization response to amphetamine. These patterns persisted after completion of the extended drug treatment. Rats with lower sensitivity to pain or with longer latency of their vocalization response to the first drug exposure showed an increased propensity for ultrasonic vocalization sensitization.
conclusionVulnerability to sensitization of frequency-modulated 50-kHz vocalization response of Sprague-Dawley rats to amphetamine, which supposedly reflects rats' propensity for amphetamine dependence, shows large inter-individual diversity. Resistance to this effect, which is evident in a majority of the rats, cannot be overcome even with prolonged intermittent drug treatment under the conditions (novelty) that promote sensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.