Evidence map›Paper›PMID 22354299›Full record

ArticleAntimicrobial agents and chemotherapy2012

No decrease in susceptibility to NVC-422 in multiple-passage studies with methicillin-resistant Staphylococcus aureus, S. aureus, Pseudomonas aeruginosa, and Escherichia coli.

Louisa D'Lima, Lisa Friedman, Lu Wang, Ping Xu, Mark Anderson, Dmitri Debabov

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Activity ofAntibiotics (Basel, Switzerland) · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Bactericidal and Fungicidal Activity ofAntimicrobial agents and chemotherapy · 2017
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. NVC-422 inactivates Staphylococcus aureus toxins.Antimicrobial agents and chemotherapy · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Louisa D'LimaNovaBay Pharmaceuticals, Inc, Emeryville, California, USA..
Lisa Friedman
Lu Wang
Ping Xu
Mark Anderson
Dmitri Debabov

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Twenty-five serial passages of Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus and 50 passages of methicillin-resistant Staphylococcus aureus resulted in no significant increase in NVC-422 MICs, while ciprofloxacin MICs increased 256-fold for E. coli and 32-fold for P. aeruginosa and S. aureus. Mupirocin, fusidic acid, and retapamulin MICs for MRSA increased 64-, 256-, and 16-fold, respectively. No cross-resistance to NVC-422 was observed with mupirocin-, fusidic acid-, and retapamulin-resistant strains.

Indexed as

Anti-Bacterial AgentsBridged Bicyclo Compounds, HeterocyclicCiprofloxacinDiterpenesDrug Resistance, Multiple, BacterialEscherichia coliFusidic AcidHumansMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMupirocinPseudomonas aeruginosaStaphylococcus aureusTaurineAnti-Bacterial AgentsBridged Bicyclo Compounds, HeterocyclicCiprofloxacinDiterpenesFusidic AcidMupirocinNVC-422retapamulinTaurine

Identifiers

PMID22354299
PMCPMC3346591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.