ArticleThe Journal of clinical investigation2012
Unraveling human natural killer cell deficiency.
Article in The Journal of clinical investigation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Controlled infection with a therapeutic virus defines the activation kinetics of human natural killer cells in vivo.Clinical and experimental immunology · 2015Trial
- NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities.Aging and disease · 2025Review
- Multi-omics pan-cancer analyses identify MCM4 as a promising prognostic and diagnostic biomarker.Scientific reports · 2024Article
- Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond.Frontiers in immunology · 2023Review
- Blood CD3-(CD56 or 16)+ natural killer cell distributions are heterogeneous in healthy adults and suppressed by azathioprine in patients with ANCA-associated vasculitides.BMC immunology · 2021Article
- NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis.Frontiers in immunology · 2021Article
- Integrative Analysis of Minichromosome Maintenance Proteins and Their Prognostic Significance in Melanoma.Frontiers in oncology · 2021Article
- Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV).International journal of molecular sciences · 2020Review
- Comprehensive role of prostate-specific antigen identified with proteomic analysis in prostate cancer.Journal of cellular and molecular medicine · 2020Article
- miRNA Regulation of NK Cells Antiviral Response in Children With Severe and/or Recurrent Herpes Simplex Virus Infections.Frontiers in immunology · 2020Article
- NK cell defects in X-linked pigmentary reticulate disorder.JCI insight · 2019Article
- Daclizumab Therapy for Multiple Sclerosis.Cold Spring Harbor perspectives in medicine · 2019Review
- Natural selection for killer receptors and their MHC class I ligands: In pursuit of gene pairs that fit well in tandem.Journal of leukocyte biology · 2019Review
- LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions.The Journal of clinical investigation · 2018Article
- Natural Killer Cells - Their Role in Tumour Immunosurveillance.Journal of clinical and diagnostic research : JCDR · 2017Review
- Biallelic mutations in IRF8 impair human NK cell maturation and function.The Journal of clinical investigation · 2017Article
- Regulation of NK Cell Activation and Effector Functions by the IL-12 Family of Cytokines: The Case of IL-27.Frontiers in immunology · 2017Review
- Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets.Frontiers in immunology · 2016Review
- Know Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control.Frontiers in immunology · 2014Review
- Multiparametric analysis of host response to murine cytomegalovirus in MHC class I-disparate mice reveals primacy of Dk-licensed Ly49G2+ NK cells in viral control.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
NK cells are a component of the innate immune system identified in animals as serving an essential role in antiviral immunity. Establishing their role in human health has been challenging, with the most direct insight coming from the study of NK cell-deficient individuals. However, NK cell deficiencies are rare, and more research is needed. In this issue of the JCI, two independent groups of researchers have simultaneously identified the genetic cause of a human NK cell deficiency as mutation in the MCM4 gene, encoding minichromosome maintenance complex component 4. These reports suggest a critical role for the minichromosome maintenance helicase complex in NK cells and NK cell-mediated host defense.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.