Evidence map›Paper›PMID 22354163›Full record

Trial reportEuropean addiction research2012

Influence of site differences between urban and rural American and Central European opioid-dependent pregnant women and neonatal outcome characteristics.

Andjela Baewert, Reinhold Jagsch, Bernadette Winklbaur, Gerda Kaiser, Kenneth Thau, Annemarie Unger, Constantin Aschauer, Manfred Weninger, Verena Metz

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European addiction research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Rural, Pregnant, and Opioid Dependent: A Systematic Review.Substance abuse : research and treatment · 2016
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Andjela BaewertDepartment of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria.
Reinhold Jagsch
Bernadette Winklbaur
Gerda Kaiser
Kenneth Thau
Annemarie Unger
Constantin Aschauer
Manfred Weninger
Verena Metz
Medical University of Vienna · ATUniversity of Vienna · AT

Funding

YOHIMBINE AS A MODEL OF ORTHOSTATIC INTOLERANCEM01RR000095 · NCRR · VANDERBILT UNIVERSITY · PI DRAKE, WONDER P. · 1985 to 2008
$38.3M
Maternal Opioid Treatment: Human Experimental ResearchR01DA015764 · NIDA · JOHNS HOPKINS UNIVERSITY · PI JONES, HENDREE E · 2004 to 2008
$5.8M
Maternal Opioid Treatment: Human Experimental ResearchR01DA015738 · NIDA · THOMAS JEFFERSON UNIVERSITY · PI KALTENBACH, KAROL A · 2004 to 2008
$3.6M
Maternal Opioid Treatment: Human Experimental ResearchR01DA015832 · NIDA · WAYNE STATE UNIVERSITY · PI STINE, SUSAN M · 2004 to 2009
$2.2M
Maternal Opioid Treatment: Human Experimental ResearchR01DA018410 · NIDA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI HEIL, SARAH H · 2004 to 2008
$2.2M
Maternal Opioid Treatment: Human ExperimentalR01DA018417 · NIDA · MEDICAL UNIVERSITY OF VIENNA · PI FISCHER, GABRIELE · 2004 to 2008
$1.8M
Maternal Opioid Treatment: Human Experimental ResearchR01DA015778 · NIDA · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M. · 2004 to 2009
$1.6M
Maternal Opioid Treatment: Human Experimental ResearchR01DA015741 · NIDA · ST. JOSEPH'S HEALTH CENTRE · PI SELBY, PETER L · 2004 to 2008
$643k
NCRR NIH HHS M01 RR000095NCRR NIH HHS M01RR00095NIDA NIH HHS R01 DA015738NIDA NIH HHS R01DA015738NIDA NIH HHS R01 DA015741NIDA NIH HHS R01DA015741NIDA NIH HHS R01 DA015764NIDA NIH HHS R01DA015764NIDA NIH HHS R01 DA015778NIDA NIH HHS R01DA015778NIDA NIH HHS R01 DA015832NIDA NIH HHS R01DA017513NIDA NIH HHS R01 DA018410NIDA NIH HHS R01DA018410NIDA NIH HHS R01 DA018417NIDA NIH HHS R01DA018417NIDA NIH HHS R01DA15832
6 · The paper itself

Abstract

backgroundMulti-center trials enable the recruitment of larger study samples, although results might be influenced by site-specific factors.

methodsSite differences of a multi-center prospective double-blind, double-dummy randomized controlled trial (7 centers: Central Europe (Vienna)/USA (3 urban/3 rural centers)) comparing safety and efficacy of methadone and buprenorphine in pregnant opioid-dependent women and their neonates.

resultsUrban US women had the highest rate of concomitant opioid (p = 0.050) and cocaine consumption (p = 0.003), the highest dropout rate (p = 0.001), and received the lowest voucher sums (p = 0.001). Viennese neonates had significantly higher Apgar scores 1 min (p = 0.001) and 5 min after birth (p < 0.001) and were more often born by cesarean section (p = 0.024). Rural US newborns had a significantly shorter neonatal abstinence syndrome treatment duration compared to Viennese and urban US sites (p = 0.006), in addition to other site-specific differences, suggesting a more severely affected group of women in the urban US sites.

conclusionThis clinical trial represents a role model for pharmacological treatment in this unique sample of pregnant women and demonstrates the clinical importance of considering site-specific factors in research and clinical practice.

Indexed as

Rural PopulationUrban PopulationAdolescentAdultBuprenorphineDouble-Blind MethodEuropeFemaleHumansInfant, NewbornMethadoneOpioid-Related DisordersPregnancyPregnancy ComplicationsPregnancy OutcomePregnant PeopleBuprenorphineMethadone

Identifiers

PMID22354163
PMCPMC3696360
OpenAlexW2048243380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.