Trial reportObstetrics and gynecology2012
Immunogenicity of trivalent inactivated influenza vaccination received during pregnancy or postpartum.
Trial report in Obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Optimal timing of influenza vaccine during pregnancy: A systematic review and meta-analysis.Influenza and other respiratory viruses · 2019Pooled it
- Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis.PloS one · 2019Pooled it
- Heterologous two-dose Ebola vaccine regimen in pregnant women in Rwanda: a randomized controlled phase 3 trial.Nature medicine · 2025Trial
- Impact of Timing of Influenza Vaccination in Pregnancy on Transplacental Antibody Transfer, Influenza Incidence, and Birth Outcomes: A Randomized Trial in Rural Nepal.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Trial
- Influenza vaccination of pregnant women protects them over two consecutive influenza seasons in a randomized controlled trial.Expert review of vaccines · 2016Trial
- Article
- The Impact of Obesity on Influenza Vaccine Immunogenicity and Antibody Transfer to the Infant During Pregnancy.Vaccines · 2024Article
- Comparative analysis of within-host dynamics of acute infection and viral rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques.bioRxiv : the preprint server for biology · 2024Article
- Factors affecting the immunogenicity of influenza vaccines in human.BMC infectious diseases · 2023Article
- Establish a Pregnant Sow-Neonate Model to Assess Maternal Immunity of a Candidate Influenza Vaccine.Vaccines · 2023Article
- Experience and attitudes on vaccinations recommended during pregnancy: survey on an Italian sample of women and consultant gynecologists.Human vaccines & immunotherapeutics · 2022Article
- SARS-CoV-2 and Influenza Vaccines in People with Excessive Body Mass-A Narrative Review.Life (Basel, Switzerland) · 2022Review
- Body Mass Index and Antibody Persistence after Measles, Mumps, Rubella and Hepatitis B Vaccinations.Vaccines · 2022Article
- Article
- Article
- Factors influencing the immunogenicity of influenza vaccines.Human vaccines & immunotherapeutics · 2021Review
- Zika virus infection during pregnancy protects against secondary infection in the absence of CD8Virology · 2021Article
- Safety, Immunogenicity, Efficacy and Effectiveness of Inactivated Influenza Vaccines in Healthy Pregnant Women and Children Under 5 Years: An Evidence-Based Clinical Review.Frontiers in immunology · 2021Review
- Article
- Role of Inflammation in Virus Pathogenesis during Pregnancy.Journal of virology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo estimate the effects of gestational age and other maternal factors on immunologic responses to influenza vaccination.
methodsAntepartum and postpartum women receiving influenza vaccination as part of routine clinical care were enrolled through four consecutive vaccination seasons (starting October 2006 through January 2010). Immunologic responses to trivalent inactivated influenza vaccine and monovalent H1N1 were assessed as well as factors influencing vaccine responsiveness. Serum samples were obtained at baseline and 4-8 weeks postvaccination.
resultsTwo hundred thirty-nine participants were included in the current analysis. Seroconversion rates to trivalent inactivated influenza vaccine strains were lowest in the first trimester (54.8%) and immediately postpartum (54.8%) and were highest in the late third trimester (69.6%) and late postpartum (69.4%); these differences were not statistically significant (P=.23). In a multivariable model, higher baseline antibody levels (P<.001) and prior year flu vaccination (P=.03) were both significantly associated with reduced odds of seroconversion. Overall, results were consistent when comparing trivalent inactivated influenza vaccine and monovalent pandemic H1N1 responses. Although there was overall no significant association between gestational age at vaccination (P=.23) or prepregnancy body mass index (P=.16), we observed somewhat lower rates of seroconversion for women vaccinated in the first trimester and for obese women.
conclusionAdequate immunologic responses to inactivated influenza vaccines were demonstrated during pregnancy and the postpartum period. No diminution of immunogenicity was observed in the third trimester, a time of increased clinical vulnerability to influenza.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.