ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Meta-analysis of executive functioning in ecstasy/polydrug users.Psychological medicine · 2016Pooled it
- Meta-analysis of molecular imaging of serotonin transporters in major depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Pooled it
- The acute effects of MDMA and ethanol administration on electrophysiological correlates of performance monitoring in healthy volunteers.Psychopharmacology · 2014Trial
- The Relationship Between Impulsivity Traits and In Vivo Cerebral Serotonin Transporter and Serotonin 2A Receptor Binding in Healthy Individuals: A Double-Tracer PET Study with C-11 DASB and C-11 MDL100907.International journal of molecular sciences · 2024Article
- Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[International journal of molecular sciences · 2022Article
- Migraine prevalence in visual snow with prior illicit drug use (hallucinogen persisting perception disorder) versus without.European journal of neurology · 2021Article
- Beyond ecstasy: Alternative entactogens to 3,4-methylenedioxymethamphetamine with potential applications in psychotherapy.Journal of psychopharmacology (Oxford, England) · 2021Review
- Neuroimaging of reward mechanisms in Gambling disorder: an integrative review.Molecular psychiatry · 2019Review
- Behavioral and Serotonergic Changes in the Frontal Cortex Following Methamphetamine Self-Administration.The international journal of neuropsychopharmacology · 2018Article
- The effects of ecstasy on neurotransmitter systems: a review on the findings of molecular imaging studies.Psychopharmacology · 2016Review
- MDMA for the treatment of mood disorder: all talk no substance?Therapeutic advances in psychopharmacology · 2015Review
- fNIRS suggests increased effort during executive access in ecstasy polydrug users.Psychopharmacology · 2015Article
- Central 5-HT neurotransmission modulates weight loss following gastric bypass surgery in obese individuals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons.Molecular psychiatry · 2014Article
- Article
- Commentary on Boileau et al. (2013): Distinguishing D2/D3 dopaminergic contributions to addictions.Addiction (Abingdon, England) · 2013Article
- Verbal memory deficits are correlated with prefrontal hypometabolism in (18)FDG PET of recreational MDMA users.PloS one · 2013Article
- 3,4-methylenedioxymethamphetamine (MDMA): current perspectives.Substance abuse and rehabilitation · 2013Review
- Integrated treatment of substance use and psychiatric disorders.Social work in public health · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
3,4-Methylenedioxymethamphetamine (MDMA), the main psychoactive component of the recreational drug ecstasy, is a potent serotonin (5-HT) releaser. In animals, MDMA induces 5-HT depletion and toxicity in 5-HT neurons. The aim of this study was to investigate both presynaptic (5-HT transporter, SERT) and postsynaptic (5-HT(2A) receptor) markers of 5-HT transmission in recently abstinent chronic MDMA users compared with matched healthy controls. We hypothesized that MDMA use is associated with lower SERT density and concomitant upregulation of 5-HT(2A) receptors. Positron emission tomography studies using the SERT ligand [¹¹C]DASB and the 5-HT(2A) receptor ligand [¹¹C]MDL 100907 were evaluated in 13 current and recently detoxified MDMA users and 13 matched healthy controls. MDMA users reported a mean duration of ecstasy use of 8 years, regular exposure, and at least 2 weeks of abstinence before the scans. SERT and 5-HT(2A) receptor availability (binding potential, BP(ND)) were analyzed with a two-tissue compartment model with arterial input function. Current recreational MDMA use was significantly associated with lower SERT BP(ND) and higher 5-HT(2A) receptor BP(ND) in cortical, but not subcortical regions. Decreased SERT BP(ND) was regionally associated with upregulated 5-HT(2A) receptor BP(ND). In light of the animal literature, the most parsimonious interpretation is that repeated exposure to MDMA in humans, even in moderate amounts, leads to damage in 5-HT neuron terminals innervating the cortex. Alterations in mood, cognition, and impulse control associated with these changes might contribute to sustain MDMA use. The reversibility of these changes upon abstinence remains to be firmly established.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.