ArticleNature communications2012
Stochastic signalling rewires the interaction map of a multiple feedback network during yeast evolution.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Cross-feeding promotes heterogeneity within yeast cell populations.Nature communications · 2024Article
- Requirements for mammalian promoters to decode transcription factor dynamics.Nucleic acids research · 2023Article
- Public good-driven release of heterogeneous resources leads to genotypic diversification of an isogenic yeast population.Evolution; international journal of organic evolution · 2022Article
- A synthetic promoter system for well-controlled protein expression with different carbon sources in Saccharomyces cerevisiae.Microbial cell factories · 2021Article
- Variation, Variegation and Heritable Gene Repression inFrontiers in genetics · 2021Review
- Comparison between Effects of Retroactivity and Resource Competition upon Change in Downstream Reporter Genes of Synthetic Genetic Circuits.Life (Basel, Switzerland) · 2019Article
- Pentose Metabolism in Saccharomyces cerevisiae: The Need to Engineer Global Regulatory Systems.Biotechnology journal · 2019Review
- Multi-component gene network design as a survival strategy in diverse environments.BMC systems biology · 2018Article
- A semi-synthetic regulon enables rapid growth of yeast on xylose.Nature communications · 2018Article
- Assigning function to natural allelic variation via dynamic modeling of gene network induction.Molecular systems biology · 2018Article
- An improved MS2 system for accurate reporting of the mRNA life cycle.Nature methods · 2018Article
- Impact of Methods on the Measurement of mRNA Turnover.International journal of molecular sciences · 2017Review
- Multiplexed gene control reveals rapid mRNA turnover.Science advances · 2017Article
- From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations.Journal of mathematical biology · 2016Article
- A cell size- and cell cycle-aware stochastic model for predicting time-dynamic gene network activity in individual cells.BMC systems biology · 2015Article
- Stress-response balance drives the evolution of a network module and its host genome.Molecular systems biology · 2015Article
- The yeast galactose network as a quantitative model for cellular memory.Molecular bioSystems · 2015Review
- Quantification of pre-mRNA escape rate and synergy in splicing.Nucleic acids research · 2014Article
- Phosphate sink containing two-component signaling systems as tunable threshold devices.PLoS computational biology · 2014Article
- A unified design space of synthetic stripe-forming networks.Nature communications · 2014Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
During evolution, genetic networks are rewired through strengthening or weakening their interactions to develop new regulatory schemes. In the galactose network, the GAL1/GAL3 paralogues and the GAL2 gene enhance their own expression mediated by the Gal4p transcriptional activator. The wiring strength in these feedback loops is set by the number of Gal4p binding sites. Here we show using synthetic circuits that multiplying the binding sites increases the expression of a gene under the direct control of an activator, but this enhancement is not fed back in the circuit. The feedback loops are rather activated by genes that have frequent stochastic bursts and fast RNA decay rates. In this way, rapid adaptation to galactose can be triggered even by weakly expressed genes. Our results indicate that nonlinear stochastic transcriptional responses enable feedback loops to function autonomously, or contrary to what is dictated by the strength of interactions enclosing the circuit.
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