Evidence map›Paper›PMID 22352829›Full record

ReviewAnnals of the New York Academy of Sciences2012

Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells.

Bo Pei, Jose Luis Vela, Dirk Zajonc, Mitchell Kronenberg

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Harnessing NKT cells for vaccination.Oxford open immunology · 2021
    Review
  5. Review
  6. Glycosphingolipids and Infection. Potential New Therapeutic Avenues.Frontiers in cell and developmental biology · 2019
    Review
  7. CD1: A Singed Cat of the Three Antigen Presentation Systems.Archivum immunologiae et therapiae experimentalis · 2017
    Review
  8. Biological roles of glycans.Glycobiology · 2017
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. The role of invariant natural killer T cells in microbial immunity.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2013
    Review
  16. Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bo PeiDivision of Developmental Immunology, La Jolla Institute for Allergy and Immunology, California, USA
Jose Luis Vela
Dirk Zajonc
Mitchell Kronenberg
La Jolla Institute for Immunology · US

Funding

Development and Function of NKT CellsR37AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2006 to 2015
$4.9M
Recognition of bacterial antigens by NKT cellsR01AI045053 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2000 to 2010
$3.3M
Differentiation of subsets of NKT cellsR01AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7M
Indirect recognition of microbes by NKT cellsR01AI069296 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2007 to 2011
$2.1M
Structural Immunology of CD1 and CD1-TCR ComplexesR01AI074952 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI ZAJONC, DIRK M · 2009 to 2013
$1.8M
Structural Immunology of CD1 and CD1-TCR ComplexesR56AI074952 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI ZAJONC, DIRK M · 2008 to 2008
$412k
NIAID NIH HHS AI45053NIAID NIH HHS AI69296NIAID NIH HHS AI71922NIAID NIH HHS AI74952NIAID NIH HHS R01 AI045053NIAID NIH HHS R01 AI069296NIAID NIH HHS R01 AI071922NIAID NIH HHS R01 AI074952NIAID NIH HHS R37 AI071922NIAID NIH HHS R56 AI074952
6 · The paper itself

Abstract

Natural killer T (NKT) cells are a T cell subpopulation that were named originally based on coexpression of receptors found on natural killer (NK) cells, cells of the innate immune system, and by T lymphocytes. The maturation and activation of NKT cells requires presentation of glycolipid antigens by CD1d, a cell surface protein distantly related to the major histocompatibility complex (MHC)-encoded antigen presenting molecules. This specificity distinguishes NKT cells from most CD4(+) and CD8(+) T cells that recognize peptides presented by MHC class I and class II molecules. The rapid secretion of a large amount of both Th1 and Th2 cytokines by activated NKT cells endows them with the ability to play a vital role in the host immune defense against various microbial infections. In this review, we summarize progress on identifying the sources of microbe-derived glycolipid antigens recognized by NKT cells and the biochemical basis for their recognition.

Indexed as

AnimalsAntigen PresentationAntigensAntigens, BacterialAntigens, CD1Binding SitesBorreliaGalactosylceramidesGlycolipidsHumansMiceModels, ImmunologicalModels, MolecularNatural Killer T-CellsReceptors, Antigen, T-CellSphingomonasalpha-galactosylceramideAntigensAntigens, BacterialAntigens, CD1GalactosylceramidesGlycolipidsReceptors, Antigen, T-Cell

Identifiers

PMID22352829
PMCPMC3336017
OpenAlexW1502561265

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.