Trial reportAnaesthesia2012
Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans.
Trial report in Anaesthesia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02924454 (An Investigation Into the Effects of Intravenous Lipid Emulsion), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.
Who cites it
19 citing papers in PubMed, 181 citations in OpenAlex.
- Effect of Intravenous Lipid Emulsion Therapy on Xenobiotic Plasma Partitioning and Short-Term Neurological Outcome in Companion Animals with Suspected Neurotoxicosis: A Case Series.Animals : an open access journal from MDPI · 2026Article
- The effect of intravenous lipid emulsion (ILE) on the pharmacokinetic/toxicokinetic dispositions of ivermectin and carprofen in rabbits.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Lipid emulsion for xenobiotic overdose: PRO.British journal of clinical pharmacology · 2023Article
- Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review.Korean journal of anesthesiology · 2023Review
- Lipid Emulsion to Treat Acute Poisonings: Mechanisms of Action, Indications, and Controversies.Pharmaceutics · 2023Review
- Reply to the letter to the editor.European heart journal. Case reports · 2023Article
- Local Anesthesia in Interventional Radiology.Seminars in interventional radiology · 2022Review
- Use of intravenous lipid emulsion therapy as a novel treatment for brevetoxicosis in sea turtles.Scientific reports · 2021Article
- Mechanisms and Efficacy of Intravenous Lipid Emulsion Treatment for Systemic Toxicity From Local Anesthetics.Frontiers in medicine · 2021Review
- Treatment of Bupropion Toxicity with Lipid Emulsion.Journal of pediatric intensive care · 2020Article
- The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study.Medicina (Kaunas, Lithuania) · 2018Article
- Intravenous lipid emulsion therapy for acute clomipramine intoxication in rats.Acute medicine & surgery · 2018Article
- Review of management in cardiotoxic overdose and efficacy of delayed intralipid use.Journal of the Intensive Care Society · 2018Article
- Lipid Emulsion for Treating Local Anesthetic Systemic Toxicity.International journal of medical sciences · 2018Review
- Use of lipid emulsion therapy in local anesthetic overdose.Saudi medical journal · 2017Review
- Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- Should we consider the infusion of lipid emulsion in the resuscitation of poisoned patients?Critical care (London, England) · 2014Review
- Resuscitation with lipid emulsion: dose-dependent recovery from cardiac pharmacotoxicity requires a cardiotonic effect.Anesthesiology · 2014Article
- Lipid emulsion infusion: resuscitation for local anesthetic and other drug overdose.Anesthesiology · 2012Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenous lipid emulsion is the recommended treatment for severe local anaesthetic intoxication. Lipid emulsion may entrap lipid soluble drugs by functioning as a 'lipid sink', but its effect on bupivacaine pharmacokinetics remains unknown. In this randomised, double-blind, crossover study, eight healthy male volunteers were infused bupivacaine 0.5mg.kg(-1) intravenously over 20 min, followed by an infusion of either intravenous lipid emulsion or Hartmann's solution for 30 min. At 20 and 30 min after the start of the infusion, the total plasma bupivacaine concentration was lower while receiving lipid emulsion than Hartmann's solution (mean difference 111 (95% CI 55-167) μg.l(-1) and 75 (95% CI 26-124 μg.l(-1) at 20 and 30 min, respectively; p<0.02). However, there were no differences in un-entrapped (non-lipid bound) or free (non-protein bound) bupivacaine plasma concentrations during the infusion. Intravenous lipid emulsion infusion reduced the context-sensitive half-life of total plasma bupivacaine from 45 (95% CI 32-76)min to 25 (95% CI 20-33)min; p=0.01. We observed no significant adverse effects of lipid emulsion. In conclusion, lipid emulsion may slightly increase the rate of bupivacaine tissue distribution. No 'lipid sink' effect was observed with the non-toxic dose of bupivacaine used.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.