Evidence map›Paper›PMID 22352530›Full record

ArticleThe Journal of the Acoustical Society of America2012

Relationships of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro.

Keith A Wear, Srinidhi Nagaraja, Maureen L Dreher, Sheng L Gibson

Abstract read
In one paragraph

Article in The Journal of the Acoustical Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Scattering in Cancellous Bone.Advances in experimental medicine and biology · 2022
    Article
  3. Ultrasonic Assessment of Cancellous Bone Based on the Two-Wave Phenomenon.Advances in experimental medicine and biology · 2022
    Article
  4. Estimation of Cadaveric Age by Ultrasonography.Diagnostics (Basel, Switzerland) · 2020
    Article
  5. Article
  6. Mechanisms of Interaction of Ultrasound With Cancellous Bone: A Review.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2020
    Review
  7. A Combined Ultrasonic Backscatter Parameter for Bone Status Evaluation in Neonates.Computational and mathematical methods in medicine · 2020
    Article
  8. Article
  9. Predicting Structural Properties of Cortical Bone by Combining Ultrasonic Attenuation and an Artificial Neural Network (ANN): 2-D FDTD Study.Image Analysis and Recognition: International Conference, ICIAR ... : proceedings. ICIAR · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. New perspectives in echographic diagnosis of osteoporosis on hip and spine.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keith A WearU.S. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Boulevard, Silver Spring, Maryland 20993, USA. keith.wear@fda.hhs.gov
Srinidhi Nagaraja
Maureen L Dreher
Sheng L Gibson

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

Ultrasound parameters (attenuation, phase velocity, and backscatter), bone mineral density (BMD), and microarchitectural features were measured on 29 human cancellous calcaneus samples in vitro. Regression analysis was performed to predict ultrasound parameters from BMD and microarchitectural features. The best univariate predictors of the ultrasound parameters were the indexes of bone quantity: BMD and bone volume fraction (BV/TV). The most predictive univariate models for attenuation, phase velocity, and backscatter coefficient yielded adjusted squared correlation coefficients of 0.69-0.73. Multiple regression models yielded adjusted correlation coefficients of 0.74-0.83. Therefore attenuation, phase velocity, and backscatter are primarily determined by bone quantity, but multiple regression models based on bone quantity plus microarchitectural features achieve slightly better predictive performance than models based on bone quantity alone.

Indexed as

Bone DensityCalcaneusHumansPhantoms, ImagingRegression AnalysisTomography, X-Ray ComputedUltrasonography

Identifiers

PMID22352530
PMCPMC6931152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.