Evidence map›Paper›PMID 22352383›Full record

ArticleOrganic letters2012

Stereoselective synthesis of cis-2,5-disubstituted pyrrolidines via Wacker-type aerobic oxidative cyclization of alkenes with tert-butanesulfinamide nucleophiles.

Joanne E Redford, Richard I McDonald, Matthew L Rigsby, Joshua D Wiensch, Shannon S Stahl

Abstract read
In one paragraph

Article in Organic letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Beilstein journal of organic chemistry · 2021
    Review
  2. Applications ofRSC advances · 2020
    Review
  3. Article
  4. Diastereoselective C-H Bond Amination for Disubstituted Pyrrolidines.Angewandte Chemie (International ed. in English) · 2017
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joanne E RedfordUniversity of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.
Richard I McDonald
Matthew L Rigsby
Joshua D Wiensch
Shannon S Stahl

Funding

Palladium-Catalyzed Oxidative Amination of AlkenesR01GM067173 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI STAHL, SHANNON S · 2003 to 2015
$3.6M
NIGMS NIH HHS R01 GM067173NIGMS NIH HHS R01 GM67163
6 · The paper itself

Abstract

Palladium(II)-catalyzed aerobic oxidative cyclization of alkenes with tethered tert-butanesulfinamides furnishes enantiopure 2,5-disubstituted pyrrolidines, originating from readily available and easily diversified starting materials. These reactions are the first reported examples of metal-catalyzed addition of sulfinamide nucleophiles to alkenes.

Indexed as

AlkenesButanesCatalysisCyclizationMolecular StructureOxidation-ReductionPyrrolidinesStereoisomerismSulfonamidesAlkenesButanesPyrrolidinesSulfonamidestert-butanesulfinamide

Identifiers

PMID22352383
PMCPMC3298084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.