ArticleArchives of dermatology2012
Viral-associated trichodysplasia: characterization of a novel polyomavirus infection with therapeutic insights.
Article in Archives of dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Sorafenib-associated Trichodysplasia Spinulosa versus Follicular Hyperkeratosis: a case report.Oxford medical case reports · 2025Article
- A rare case of viral-associated trichodysplasia spinulosa in a patient with chronic lymphocytic leukemia.International journal of women's dermatology · 2023Article
- Trichodysplasia spinulosa: a comprehensive review of the disease and its treatment.Journal of the European Academy of Dermatology and Venereology : JEADV · 2021Review
- Facial Spinulate Demodicosis.Clinical, cosmetic and investigational dermatology · 2021Article
- Photodynamic therapy for the treatment of trichodysplasia spinulosa in an Asian renal transplant recipient: A case report and review of literature.JAAD case reports · 2021Article
- Widespread keratosis pilaris-like eruption in an immunocompromised child.JAAD case reports · 2019Article
- The Biology and Clinical Features of Cutaneous Polyomaviruses.The Journal of investigative dermatology · 2019Review
- Trichodysplasia Spinulosa in a 7-Year-Old Boy Managed Using Physical Extraction of Keratin Spicules.Pediatric dermatology · 2017Article
- Trichodysplasia spinulosa: A rare complication of immunosuppression.JAAD case reports · 2016Article
- Two cases of trichodysplasia spinulosa responsive to compounded topical cidofovir 3% cream.JAAD case reports · 2015Article
- Burkitt lymphoma research in East Africa: highlights from the 9(th) African organization for research and training in cancer conference held in Durban, South Africa in 2013.Infectious agents and cancer · 2014Article
- Electron microscopy: essentials for viral structure, morphogenesis and rapid diagnosis.Science China. Life sciences · 2013Review
- Peptide immunization elicits polyomavirus-specific MHC class ib-restricted CD8 T cells in MHC class ia allogeneic mice.Viral immunology · 2013Article
- Human polyomavirus reactivation: disease pathogenesis and treatment approaches.Clinical & developmental immunology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundViral-associated trichodysplasia of immunosuppression is a rare cutaneous eruption that is characterized by follicularly based shiny papules and alopecia with characteristic histopathologic findings of abnormally anagen follicules with excessive inner root sheath differentiation. Prior reports have described the histopathologic characteristics on vertical sections; however, to our knowledge, immunohistochemical analysis of polyomavirus proteins has not been previously performed. OBSERVATIONS: We discuss the thorough diagnostic evaluation and therapy of an unusual case of viral-associated trichodysplasia due to a newly described human polyomavirus that occurred in a patient with posttreatment chronic lymphocytic leukemia and an abnormal white blood cell count. Unique to our study is the immunohistochemical staining for the polyomavirus middle T antigen, which demonstrated positive staining of cellular inclusions within keratinocytes that compose the inner root sheath. Further evaluation with scanning electron microscopy and polymerase chain reaction analysis of viral DNA confirmed the presence of the virus. Treatment with topical cidofovir resulted in dramatic clinical improvement and hair regrowth.
conclusionsSeveral tools, including immunohistochemical staining for the polyomavirus middle T antigen, can be used to identify the pathogenic virus associated with viral-associated trichodysplasia. This case highlights the utility of multiple diagnostic modalities and a robust response to a topical therapeutic agent, cidofovir.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.