ArticleThe Journal of biological chemistry2012
Subcellular localization of talin is regulated by inter-domain interactions.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Endothelial ENaC-α Restrains Oxidative Stress in Lung Capillaries in Murine Pneumococcal Pneumonia-associated Acute Lung Injury.American journal of respiratory cell and molecular biology · 2025Article
- TLN1: an oncogene associated with tumorigenesis and progression.Discover oncology · 2024Review
- ConFERMing the role of talin in integrin activation and mechanosignaling.Journal of cell science · 2023Article
- Intrinsically disordered region of talin's FERM domain functions as an initial PIPBiophysical journal · 2023Article
- Plasma Concentrations of Vinculin versus Talin-1 in Coronary Artery Disease.Medical sciences (Basel, Switzerland) · 2022Article
- Profiling the responsiveness of focal adhesions of human cardiomyocytes to extracellular dynamic nano-topography.Bioactive materials · 2022Article
- Mechanical stress determines the configuration of TGFβ activation in articular cartilage.Nature communications · 2021Article
- Immunological Role and Prognostic Value of APBB1IP in Pan-Cancer Analysis.Journal of Cancer · 2021Article
- Binding of Rap1 and Riam to Talin1 Fine-Tune β2 Integrin Activity During Leukocyte Trafficking.Frontiers in immunology · 2021Article
- Aldosterone up-regulates voltage-gated potassium currents and NKCC1 protein membrane fractions.Scientific reports · 2020Article
- Article
- High Plasma Levels of Soluble Talin-1 in Patients with Coronary Artery Disease.Disease markers · 2020Article
- Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation.Journal of cell science · 2019Article
- Kindlin-1 Regulates Epidermal Growth Factor Receptor Signaling.The Journal of investigative dermatology · 2019Article
- Adhesions Assemble!-Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion.Frontiers in molecular biosciences · 2019Review
- The tale of two talins - two isoforms to fine-tune integrin signalling.FEBS letters · 2018Review
- Differential Binding of Active and Inactive Integrin to Talin.The protein journal · 2018Article
- Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex.FEBS letters · 2018Article
- Molecular stretching modulates mechanosensing pathways.Protein science : a publication of the Protein Society · 2017Review
- Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form.Biochemistry · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Talin, which is composed of head (THD) and rod domains, plays an important role in cell adhesion events in diverse species including most metazoans and Dictyostelium discoideum. Talin is abundant in the cytosol; however, it mediates adhesion by associating with integrins in the plasma membrane where it forms a primary link between integrins and the actin cytoskeleton. Cells modulate the partitioning of talin between the plasma membrane and the cytosol to control cell adhesion. Here, we combine nuclear magnetic resonance spectroscopy (NMR) with subcellular fractionation to characterize two distinct THD-rod domain interactions that control the interaction of talin with the actin cytoskeleton or its localization to the plasma membrane. An interaction between a discrete vinculin-binding region of the rod (VBS1/2a; Tln1(482-787)), and the THD restrains talin from interacting with the plasma membrane. Furthermore, we show that vinculin binding to VBS1/2a results in talin recruitment to the plasma membrane. Thus, we have structurally defined specific inter-domain interactions between THD and the talin rod domain that regulate the subcellular localization of talin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.