ArticleThe Journal of biological chemistry2012
Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp.
Article in The Journal of biological chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Stem cell-driven biomedical technologies for tooth regeneration: engineering scaffolds, organoid models, and molecular targeted strategies.Stem cell research & therapy · 2026Review
- Soluble Notch agonist enables human ameloblast maturation and enamel-like tissue formation for tooth regeneration.International journal of oral science · 2026Article
- Article
- The intricacies of tooth enamel: Embryonic origin, development and human genetics.Journal of structural biology · 2024Review
- MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.Experimental & molecular medicine · 2024Article
- METTL3-mediated pre-miR-665/DLX3 mExperimental & molecular medicine · 2024Article
- Regeneration of Pulp and Radicular Tissues in a Nonvital Avulsed Tooth with Open Apex: A Case Report.International journal of clinical pediatric dentistry · 2024Article
- An animal study on the effectiveness of platelet-rich plasma as a direct pulp capping agent.Scientific reports · 2024Article
- Single-cell census of human tooth development enables generation of human enamel.Developmental cell · 2023Article
- The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes.Frontiers in cell and developmental biology · 2023Review
- The Genes Involved in Dentinogenesis.Organogenesis · 2022Article
- Review
- Transcriptional Regulation of Jaw Osteoblasts: Development to Pathology.Journal of dental research · 2022Article
- Epigenetic Regulation of Methylation in Determining the Fate of Dental Mesenchymal Stem Cells.Stem cells international · 2022Review
- Odontoblast processes of the mouse incisor are plates oriented in the direction of growth.Anatomical record (Hoboken, N.J. : 2007) · 2021Article
- Genome-Wide Association Study (GWAS) of dental caries in diverse populations.BMC oral health · 2021Article
- Trafficking and secretion of keratin 75 by ameloblastsThe Journal of biological chemistry · 2019Article
- Consortium-based genome-wide meta-analysis for childhood dental caries traits.Human molecular genetics · 2018Article
- DLX3 Inhibits the Proliferation of Human Dental Pulp Cells Through Inactivation of Canonical Wnt/β-Catenin Signaling Pathway.Frontiers in physiology · 2018Article
- BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
During development, Dlx3 is expressed in ectodermal appendages such as hair and teeth. Thus far, the evidence that Dlx3 plays a crucial role in tooth development comes from reports showing that autosomal dominant mutations in DLX3 result in severe enamel and dentin defects leading to abscesses and infections. However, the normal function of DLX3 in odontogenesis remains unknown. Here, we use a mouse model to demonstrate that the absence of Dlx3 in the neural crest results in major impairment of odontoblast differentiation and dentin production. Mutant mice develop brittle teeth with hypoplastic dentin and molars with an enlarged pulp chamber and underdeveloped roots. Using this mouse model, we found that dentin sialophosphoprotein (Dspp), a major component of the dentin matrix, is strongly down-regulated in odontoblasts lacking Dlx3. Using ChIP-seq, we further demonstrate the direct binding of Dlx3 to the Dspp promoter in vivo. Luciferase reporter assays determined that Dlx3 positively regulates Dspp expression. This establishes a regulatory pathway where the transcription factor Dlx3 is essential in dentin formation by directly regulating a crucial matrix protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.