Evidence map›Paper›PMID 22351642›Full record

ReviewNMR in biomedicine2012

New advances in MR-compatible bioartificial liver.

Rex E Jeffries, Jeffrey M Macdonald

Open access · greenAbstract readReview
In one paragraph

Review in NMR in biomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Toxicology research · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rex E JeffriesDepartment of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7575, USA.
Jeffrey M Macdonald
University of North Carolina at Chapel Hill · US

Funding

X-RAY RESEARCH AND DEVELOPMENT WITH/WITHOUT LIVE ANIMALSP41RR005959 · NCRR · DUKE UNIVERSITY · PI DZAU, VICTOR J · 1990 to 2011
$16.0M
FURANOCOUMARINS AND DRUGS EFFECT ON CYP3A4R37GM038149 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WATKINS, PAUL B · 1998 to 2007
$3.8M
Anti-inflammatory Effects of Novel Minor Cannabinoids and Terpenes on Cellular and Murine Models of HIV and HIV ProteinsR01DA052851 · NIDA · UNIVERSITY OF MISSISSIPPI · PI ASHPOLE, NICOLE M, PARIS, JASON RICHARD · 2020 to 2023
$1.4M
Human Enterohepatic Cell Model for Predictive ToxicologyR21GM075941 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACDONALD, JEFFREY M. · 2006 to 2008
$1.0M
BIOARTIFICIAL LIVERS FROM HEPATIC PROGENITOR CELLSR01DK052851 · NIDDK · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI REID, LOLA M · 1998 to 2001
$620k
Preclinical Fluxomic Model of Drug-Induced Liver InjuryF31DK082172 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JEFFRIES, REX E. · 2008 to 2009
$58k
REGULATION OF P-450 III CYTOCHROMES IN LIVER &INTESTINER01GM038149 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WATKINS, PAUL B · 1986 to 1997
–
NMR ANALYSIS OF BIOARTIFICAL LIVER FROM PROGENITORSF32DK009713 · NIDDK · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI MACDONALD, JEFFREY M. · 1997 to 1998
–
NCRR NIH HHS P41 RR005959NCRR NIH HHS P41-RR05959NIDA NIH HHS R01 DA052851NIDDK NIH HHS 1F31DK082172-01NIDDK NIH HHS F31 DK082172NIDDK NIH HHS F32 DK009713NIDDK NIH HHS F32 DK09713NIDDK NIH HHS R01 DK52851NIGMS NIH HHS GM075941NIGMS NIH HHS GM38149NIGMS NIH HHS R21 GM075941NIGMS NIH HHS R37 GM038149
6 · The paper itself

Abstract

MR-compatible bioartificial liver (BAL) studies have been performed for 30 years and are reviewed. There are two types of study: (i) metabolism and drug studies using multinuclear MRS; primarily short-term (< 8 h) studies; (ii) the use of multinuclear MRS and MRI to noninvasively define the features and functions of BAL systems for long-term liver tissue engineering. In the latter, these systems often undergo not only modification of the perfusion system, but also the construction of MR radiofrequency probes around the bioreactor. We present novel MR-compatible BALs and the use of multinuclear MRS ((13)C, (19)F, (31)P) for the noninvasive monitoring of their growth, metabolism and viability, as well as (1)H MRI methods for the determination of flow profiles, diffusion, cell distribution, quality assurance and bioreactor integrity. Finally, a simple flexible coil design and circuit, and life support system, are described that can make almost any BAL MR-compatible.

Indexed as

BioreactorsLiver, ArtificialAnimalsCell Culture TechniquesHepatocytesHumansMagnetic Resonance ImagingOxygenPharmaceutical PreparationsTissue EngineeringOxygenPharmaceutical Preparations

Identifiers

PMID22351642
PMCPMC4332620
OpenAlexW2151810734

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.