ReviewThe Journal of physiology2012
Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors.
Review in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
90 citing papers in PubMed, 191 citations in OpenAlex.
- Independent influence of age on heart rate recovery after flywheel exercise in trained men and women.Scientific reports · 2021Trial
- Cerebral vasomotor reactivity during hypo- and hypercapnia across the adult lifespan.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Trial
- Short-term water deprivation does not increase blood pressure variability or impair neurovascular function in healthy young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women.Journal of the American Heart Association · 2016Trial
- Aging enhances autonomic support of blood pressure in women.Hypertension (Dallas, Tex. : 1979) · 2014Trial
- Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis.Experimental physiology · 2026Article
- A Four-Phenotype Model for Risk Stratification in Heart Failure with Preserved and Mildly Reduced Ejection Fraction: The Role of Sex and Diabetes.Biomedicines · 2026Article
- The vascular contribution to cognitive decline in ageing and dementia.Nature reviews. Neuroscience · 2025Review
- Vasomotor symptoms of menopause, sympathetic activity, and blood pressure in postmenopausal females.American journal of physiology. Heart and circulatory physiology · 2025Article
- Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.Autonomic neuroscience : basic & clinical · 2025Review
- Eight months of marathon school training reduced blood pressure, systemic vascular resistance and extracellular water volume.Scientific reports · 2025Article
- Differences in sex and age response to single pill combination based antihypertensive therapy reflecting in blood pressure and arterial stiffness.Journal of hypertension · 2025Article
- Flow-mediated dilation decreases in women, but not men, following mild acute intermittent hypoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- The impact of salt consumption on cardiometabolic and cognitive health in aged female rats.Scientific reports · 2024Article
- Real-time Continuous Blood Pressure Estimation with Contact-free Bedseismogram.IEEE International Conference on Communications : [proceedings]. IEEE International Conference on Communications · 2024Article
- Influence of sex and sedentary conditions on sympathetic burst characteristics in prepubertal, postpubertal, and young adult rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Differences in heart rate responses to upright posture are associated with variations in the high-frequency power of heart rate variability.American journal of physiology. Heart and circulatory physiology · 2024Article
- Aging and sympathetic transduction to blood pressure in humans: methodological and physiological considerations.American journal of physiology. Heart and circulatory physiology · 2024Article
- Strain- and sex-specific differences in intestinal microhemodynamics and gut microbiota composition.Gastroenterology report · 2024Article
- Mean Arterial Pressure and Cerebral Hemodynamics Across The Lifespan: A Cross-Sectional Study From Human Connectome Project-Aging.Journal of magnetic resonance imaging : JMRI · 2023Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young women tend to have lower blood pressure, and less risk of hypertension, compared to young men. As people age, both blood pressure and the risk of hypertension increase in both sexes; this occurs most strikingly in women after menopause. However, the mechanisms for these influences of sex and age remain incompletely understood. In this review we are specifically interested in the interaction between neural (sympathetic nerve activity; SNA) and haemodynamic factors (cardiac output, blood pressure and vascular resistance) and how these change with sex and age. While peripheral vascular SNA can vary 7- to 10-fold among normotensive young men and women, it is reproducible in a given individual. Surprisingly, higher levels of SNA are not associated with higher blood pressures in these groups. In young men, high SNA is associated with higher total peripheral vascular resistance (TPR), and appears to be balanced by lower cardiac output and less peripheral vascular responsiveness to adrenergic stimulation. Young women do not exhibit the SNA-TPR relationship. Recent evidence suggests that β-adrenergic vasodilatation offsets the vasoconstrictor effects of α-adrenergic vasoconstriction in young women, which may contribute to the generally lower blood pressures in this group. Sympathetic nerve activity increases with age, and in groups over 40, levels of SNA are more tightly linked to levels of blood pressure. The potentially protective β-adrenergic effect seen in young women appears to be lost after menopause and probably contributes to the increased blood pressure and increased risk of hypertension seen in older women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.