ArticleMolecular biotechnology2013
Identification of a xylitol dehydrogenase gene from Kluyveromyces marxianus NBRC1777.
Article in Molecular biotechnology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Lignocellulosic xylitol production from corncob using engineeredFrontiers in bioengineering and biotechnology · 2022Article
- Establishment ofJournal of fungi (Basel, Switzerland) · 2021Article
- Genetic basis of the highly efficient yeast Kluyveromyces marxianus: complete genome sequence and transcriptome analyses.Biotechnology for biofuels · 2015Article
- Effect of oxygenation and temperature on glucose-xylose fermentation in Kluyveromyces marxianus CBS712 strain.Microbial cell factories · 2014Article
- Improved xylose fermentation of Kluyveromyces marxianus at elevated temperature through construction of a xylose isomerase pathway.Journal of industrial microbiology & biotechnology · 2013Article
- Improving ethanol and xylitol fermentation at elevated temperature through substitution of xylose reductase in Kluyveromyces marxianus.Journal of industrial microbiology & biotechnology · 2013Article
- Genome sequence of the thermotolerant yeast Kluyveromyces marxianus var. marxianus KCTC 17555.Eukaryotic cell · 2012Article
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Authors and funding
7 authors.
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Abstract
Xylitol dehydrogenase (XDH) (EC 1.1.1.9) is one of the key enzymes in the xylose fermentation pathway in yeast and fungi. A xylitol dehydrogenase gene (XYL2) encoding a XDH was cloned from Kluyveromyces marxianus NBRC 1777, and the in vivo function was validated by disruption and complementation analysis. The highest activity of KmXDH could be observed at pH 9.5 during 55°C. The values of k(cat)/K(m) indicate that KmXDH prefers NAD(+) to NADP(+) (k(cat)/K(m NAD)(+) 3681/min mM and k(cat)/K(m NADP)(+) 1361/min mM). The different coenzyme preference between KmXR and KmXDH caused an accumulation of NADH in the xylose utilization pathway. The redox imbalance may be one of the reasons to cause the poor xylose fermentation under oxygen-limited conditions in K. marxianus NBRC1777.
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