ReviewInternational journal of hematology2012
Molecular nature of radiation injury and DNA repair disorders associated with radiosensitivity.
Review in International journal of hematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- DNA repair and the contribution to chemotherapy resistance.Genome medicine · 2025Review
- Predictive value of 8-hydroxy-2'-deoxyguanosine and 8-nitroguanine production in radiation-induced skin damage after postoperative breast cancer radiotherapy.Exploration of targeted anti-tumor therapy · 2025Article
- TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond.Cancer metastasis reviews · 2024Review
- Complex Interplay between DNA Damage and Autophagy in Disease and Therapy.Biomolecules · 2024Review
- Utilizing a Second Flap to Address the Effect of Postradiotherapy Soft Tissue Fibrosis in Head and Neck Malignancy.Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India · 2024Article
- The Predictive Value of 8-Hydroxy-Deoxyguanosine (8-OHdG) Serum Concentrations in Irradiated Non-Small Cell Lung Carcinoma (NSCLC) Patients.Biomedicines · 2024Article
- Improving the efficacy of combined radiotherapy and immunotherapy: focusing on the effects of radiosensitivity.Radiation oncology (London, England) · 2023Review
- Identification of S100A9 as a Potential Inflammation-Related Biomarker for Radiation-Induced Lung Injury.Journal of clinical medicine · 2023Article
- Article
- Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers.International journal of radiation oncology, biology, physics · 2021Review
- VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance.Signal transduction and targeted therapy · 2021Article
- A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies.Scientific reports · 2017Article
- Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer.Genetics and molecular biology · 2015Article
- Ubiquitination in disease pathogenesis and treatment.Nature medicine · 2014Review
- A novel radioprotective function for the mitochondrial tumor suppressor protein Fus1.Cell death & disease · 2013Article
- ID1 affects the efficacy of radiotherapy in glioblastoma through inhibition of DNA repair pathways.Medical oncology (Northwood, London, England) · 2013Article
- Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.Nature communications · 2013Article
- Reversion of the ErbB malignant phenotype and the DNA damage response.Experimental and molecular pathology · 2012Review
- 8-Hydroxy-2'-Deoxyguanosine and 8-Nitroguanine Production and Detection in Blood Serum of Breast Cancer Patients in Response to Postoperative Complementary External Ionizing Irradiation of Normal Tissues.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ionizing radiation (IR), as well as a wide variety of chemicals and reactive oxygen species, can cause insults in DNA integrity. However, IR is distinct from other agents in that produces clustered DNA damage, particularly double-strand DNA breaks (DSBs). The discovery of radiosensitive human diseases has revealed that the molecular mechanisms underlying the biological effects of IR impact cellular responses to and repair of DSBs. One class of diseases, including ataxia-telangiectasia, displays a defect in checkpoint response to DSBs. Another class of diseases exhibits severe combined immunodeficiency and defects in DSB repair. Importantly, radiosensitive human diseases are also associated with increased risks of leukemia/lymphoma. In this review, we summarize the molecular nature of IR-induced DNA damage, and provide an overview of the molecular mechanisms of checkpoint response to and repair of DSBs. Lastly, we discuss the roles of these mechanisms in the development of the immune system and the suppression of lymphoma/leukemia, based on the clinical features and experiments with model mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.