ReviewJournal of molecular neuroscience : MN2012
The F-actin cortex in chromaffin granule dynamics and fusion: a minireview.
Review in Journal of molecular neuroscience : MN, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Visualization of Exo- and Endocytosis Membrane Dynamics with Super-Resolution STED Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Vesicle Fusion as a Target Process for the Action of Sphingosine and Its Derived Drugs.International journal of molecular sciences · 2022Review
- Emerging evidence for the modulation of exocytosis by signalling lipids.FEBS letters · 2018Review
- Analysis of the calcium paradox of renin secretion.American journal of physiology. Renal physiology · 2018Article
- The high-affinity calcium sensor synaptotagmin-7 serves multiple roles in regulated exocytosis.The Journal of general physiology · 2018Review
- Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Small molecules demonstrate the role of dynamin as a bi-directional regulator of the exocytosis fusion pore and vesicle release.Molecular psychiatry · 2015Article
- Organization and dynamics of SNARE proteins in the presynaptic membrane.Frontiers in physiology · 2015Review
- Super-resolution microscopy in studying neuroendocrine cell function.Frontiers in neuroscience · 2013Review
- The role of the cytoskeleton at the immunological synapse.Immunological reviews · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromaffin granules are restrained in a dense cortical cytoskeleton before releasing their complex mix of active substances in response to cell stimulation. In recent years, the complex organization and dynamics of the chromaffin cell cortex has been unveiled through its analysis with a range of techniques to visualize this structure, including confocal fluorescence, transmitted light, and evanescent field microscopy. Accordingly, it has become apparent that the cortex is a dense F-actin mesh that contains open polygonal spaces through which vesicles can access the submembrane space. In addition to its retentive role, this structure also influences vesicle motion in both the resting state and during cell stimulation with secretagogues. During secretion, the chromaffin cell cortex undergoes a complex reorganization, helping to replenish the empty fast releasable pool of vesicles. Such changes in the cortical cytoskeleton and in the vesicle motion are governed by the activity of molecular motors, such as myosins II and Va. Interestingly, the F-actin/myosin II network also affects the final stages of exocytosis, which involve the opening and expansion of the fusion pore, and the extrusion of the vesicles contents.
Indexed as
Identifiers
22350991What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.