ArticleCell and tissue research2012
Cardiac telocytes - their junctions and functional implications.
Article in Cell and tissue research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.
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Who cites it
150 citing papers in PubMed, 252 citations in OpenAlex.
- An Enriched Primary Culture Reveals Morphological Heterogeneity of Rat Testicular Telocytes.Cells · 2026Article
- Telocytes Twenty Years on: A Critical Reappraisal of Identity, Function, and Pathological Relevance.International journal of molecular sciences · 2026Review
- Young cardiac telocyte-derived exosomes rejuvenate aging hearts in rats.Frontiers in cell and developmental biology · 2026Article
- The impact of natural and engineered extracellular vesicles on post-myocardial infarction angiogenesis.Stem cell research & therapy · 2025Review
- Identification and localization of telocyte-like cells in human umbilical cord stroma.Scientific reports · 2025Article
- Telocytes: history, origin, identification, structure, distribution, and functions.Histochemistry and cell biology · 2025Review
- Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models.Cell biology and toxicology · 2025Article
- Transcriptomic and Histological Characterization of Telocytes in the Human Dorsal Root Ganglion.The Journal of comparative neurology · 2025Article
- Distribution characteristics and morphological comparison of telocytes in the aortic bulb and myocardium of yak heart.BMC veterinary research · 2025Article
- Elucidating the preventive and therapeutic effects of cardiac telocytes paracrine microRNAs on ischemic heart disease.Frontiers in cardiovascular medicine · 2025Article
- Transcriptomic and histological characterization of telocytes in the human dorsal root ganglion.bioRxiv : the preprint server for biology · 2024Article
- Immunohistochemical-properties of the dermal embryonic telocytes.Scientific reports · 2024Article
- Immunohistochemical properties of embryonic telocytes in a myogenic microenvironment.Scientific reports · 2024Article
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- Dynamic relationship among extracellular matrix and body wall cells in Hirudo verbana morphogenesis.Cell and tissue research · 2024Article
- Adeno-associated virus-based approach for genetic modification of cardiac fibroblasts in adult rat hearts.Physiological reports · 2024Article
- A transmission electron microscopy investigation suggests that telocytes, skeletal muscles, myoblasts, and stem cells in common carp (Cyprinus carpio) respond to salinity challenges.BMC veterinary research · 2024Article
- Vascular endothelial growth factor facilitates the effects of telocytes on tumor cell proliferation and migration.Frontiers in cell and developmental biology · 2024Article
- Morphological changes in intraepithelial and stromal telocytes in Cyprinus carpio in response to salinity stress.Scientific reports · 2023Article
- Stromal cell-derived factor 1 (SDF-1) increases the number of telocytes in ex vivo and in vitro assays.Histochemistry and cell biology · 2023Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telocytes (TCs) form a cardiac network of interstitial cells. Our previous studies have shown that TCs are involved in heterocellular contacts with cardiomyocytes and cardiac stem/progenitor cells. In addition, TCs frequently establish 'stromal synapses' with several types of immunoreactive cells in various organs ( www.telocytes.com ). Using electron microscopy (EM) and electron microscope tomography (ET), we further investigated the interstitial cell network of TCs and found that TCs form 'atypical' junctions with virtually all types of cells in the human heart. EM and ET showed different junction types connecting TCs in a network (puncta adhaerentia minima, processus adhaerentes and manubria adhaerentia). The connections between TCs and cardiomyocytes are 'dot' junctions with nanocontacts or asymmetric junctions. Junctions between stem cells and TCs are either 'stromal synapses' or adhaerens junctions. An unexpected finding was that TCs have direct cell-cell (nano)contacts with Schwann cells, endothelial cells and pericytes. Therefore, ultrastructural analysis proved that the cardiac TC network could integrate the overall 'information' from vascular system (endothelial cells and pericytes), nervous system (Schwann cells), immune system (macrophages, mast cells), interstitium (fibroblasts, extracellular matrix), stem cells/progenitors and working cardiomyocytes. Generally, heterocellular contacts occur by means of minute junctions (point contacts, nanocontacts and planar contacts) and the mean intermembrane distance is within the macromolecular interaction range (10-30 nm). In conclusion, TCs make a network in the myocardial interstitium, which is involved in the long-distance intercellular signaling coordination. This integrated interstitial system appears to be composed of large homotropic zones (TC-TC junctions) and limited (distinct) heterotropic zones (heterocellular junctions of TCs).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.