ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2012
Helicobacter pylori in gallbladder mucosa in patients with gallbladder disease.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The Relationship betweenCanadian journal of gastroenterology & hepatology · 2021Pooled it
- Early detection of gallbladder cancer: Current status and future perspectives.World journal of clinical oncology · 2025Review
- Review
- Gallbladder cancer: Progress in the Indian subcontinent.World journal of clinical oncology · 2024Review
- The link betweenAnnals of hepato-biliary-pancreatic surgery · 2023Review
- Article
- Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.Bioinformation · 2019Article
- Unusual Manifestation of LiveInternational journal of molecular sciences · 2018Article
- Association of seropositivity to Helicobacter species and biliary tract cancer in the ATBC study.Hepatology (Baltimore, Md.) · 2014Article
- Discovery of Helicobacter pylori in gallbladder.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2012Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHelicobacter species have been found to be associated with biliary tract diseases. This prospective study was done to determine the prevalence of H. pylori in the biliary tract of patients suffering from gallbladder disease.
methodsForty-nine patients undergoing laparoscopic/open cholecystectomy for benign biliary tract diseases were investigated with urea breath test for H. pylori infection of gastric antrum. Bile and gallbladder tissues were studied for presence of H. pylori by rapid urease test, histopathological examination, culture and PCR analysis. Gallbladder specimens from two patients who underwent Whipple's operation and from 10 cadavers were studied as controls.
resultsThe mean (SD) age of patients was 42.4 (11.1) years. Urea breath test was positive in 17 (34.6%) cases. Rapid urease test was negative in all the cases. There was no evidence of H. pylori infection of gallbladder on histopathological examination using H&E, Giemsa and Warthin Starry stains. H. pylori DNA were detected in 16 patients (32.6%) and none of the 12 controls by PCR analysis (p = 0.025). The presence of H. pylori DNA in bile and/or gallbladder was associated with positive urea breath test, (p < 0.0001). Other factors like age, gender, jaundice and cholestasis were not associated with H. pylori infection of bile and gallbladder.
conclusionsNearly three quarters of patients with positive urea breath test have detectable H. pylori DNA in gallbladder tissue. The significance of these findings needs to be further evaluated.
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