ReviewHuman genetics2012
Drosophila melanogaster as a model to study drug addiction.
Review in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuromodulatory circuit effects on Drosophila feeding behaviour and metabolism.Scientific reports · 2017Pooled it
- Non-Mammalian Models for Mitochondria Research in CNS Disorders.Biomolecules · 2026Review
- Behavioural and physiological impacts of varying doses of methotrexate on Drosophila melanogaster.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- The use ofFrontiers in cell and developmental biology · 2026Review
- Article
- Juvenile hormone regulates the maturation of sexually dimorphic naive ethanol olfactory preference inRoyal Society open science · 2025Article
- Neuroecology of alcohol risk and reward: Methanol boosts pheromones and courtship success inScience advances · 2025Article
- Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways.Nature metabolism · 2024Article
- TBI and Tau Loss of Function Both Affect Naïve Ethanol Sensitivity inInternational journal of molecular sciences · 2024Article
- Distinct and Dynamic Changes in the Temporal Profiles of Neurotransmitters inPharmaceuticals (Basel, Switzerland) · 2023Article
- The Effects of Ethanol and Acetic acid on Behaviour of Extranidal Workers of the Narrow-Headed AntAnimals : an open access journal from MDPI · 2023Article
- Article
- Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science.Current protocols · 2023Review
- Continuous, long-term crawling behavior characterized by a robotic transport system.bioRxiv : the preprint server for biology · 2023Article
- Dozing Off With Drosophila: The Effect of Disrupted Circadian Rhythms and Sleep Disturbance on Mortality, Mood, and Addiction.Neuroscience insights · 2023Article
- Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling.Frontiers in molecular neuroscience · 2023Review
- Caffeine Delays Ethanol-Induced Sedation inBiology · 2022Article
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Functional Genomic Analysis of Amphetamine Sensitivity inFrontiers in psychiatry · 2022Article
- Ibrutinib as a potential therapeutic for cocaine use disorder.Translational psychiatry · 2021Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Animal studies have been instrumental in providing knowledge about the molecular and neural mechanisms underlying drug addiction. Recently, the fruit fly Drosophila melanogaster has become a valuable system to model not only the acute stimulating and sedating effects of drugs but also their more complex rewarding properties. In this review, we describe the advantages of using the fly to study drug-related behavior, provide a brief overview of the behavioral assays used, and review the molecular mechanisms and neural circuits underlying drug-induced behavior in flies. Many of these mechanisms have been validated in mammals, suggesting that the fly is a useful model to understand the mechanisms underlying addiction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.