ArticleClinical research in cardiology : official journal of the German Cardiac Society2012
The risk-to-benefit ratio of transcatheter aortic valve implantation in specific patient cohorts: a single-centre experience.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors of Permanent Pacemaker Implantation in Patients Undergoing Transcatheter Aortic Valve Replacement - A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2021Pooled it
- Functional status and quality of life after transcatheter aortic valve replacement: a systematic review.Annals of internal medicine · 2014Pooled it
- Comparison 30-day clinical complications between transfemoral versus transapical aortic valve replacement for aortic stenosis: a meta-analysis review.Journal of cardiothoracic surgery · 2013Pooled it
- Impact of left ventricular conduction defect with or without need for permanent right ventricular pacing on functional and clinical recovery after TAVR.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Feasibility of sheathless transfemoral aortic valve implantation in patients with small access vessel diameters.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Trial
- Impact of Transcatheter Aortic Valve Implantation (TAVI) on Left Ventricular Mass, Volumes, and Pressure. A Single-center Echocardiographic Analysis.Journal of the Saudi Heart Association · 2025Article
- Risk stratification in patients undergoing interventional left atrial appendage occlusion-Prognostic impact of EuroSCORE II.Clinical cardiology · 2020Article
- Ruptures of the device landing zone in patients undergoing transcatheter aortic valve implantation: an analysis of TAVI Karlsruhe (TAVIK) patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Effects of transcatheter aortic valve implantation on ascending aorta wall elastic properties: Tissue Doppler imaging and strain Doppler echocardiography study.International journal of cardiology. Heart & vessels · 2014Article
- Transcatheter aortic valve implantation in patients with severely reduced left ventricular systolic function: a single-center experience.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Effect of gender differences on 1-year mortality after transcatheter aortic valve implantation for severe aortic stenosis: results from a multicenter real-world registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Development of a risk score for outcome after transcatheter aortic valve implantation.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- The year in clinical research in cardiology: the official journal of the German Cardiac Society (Deutsche Gesellschaft für Kardiologie--Herz- und Kreislaufforschung).Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Can postoperative mean transprosthetic pressure gradient predict survival after aortic valve replacement?Clinical research in cardiology : official journal of the German Cardiac Society · 2014Observational
- Effects of transcatheter aortic valve implantation on left ventricular mass and global longitudinal strain: tissue Doppler and strain evaluation.Heart, lung and vessels · 2014Article
- Safety and efficacy of the subclavian access route for TAVI in cases of missing transfemoral access.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Left atrial diameter, aortic mean gradient, and hemoglobin for risk stratification in patients undergoing transcatheter aortic valve implantation.Clinical cardiology · 2013Article
- The groin first approach for transcatheter aortic valve implantation: are we pushing the limits for transapical implantation?Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Transapical aortic valve implantation - What have we learnt? Quo vadis?Cardiovascular diagnosis and therapy · 2012Article
- Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.Clinical research in cardiology : official journal of the German Cardiac Society · 2012Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscatheter aortic valve implantation (TAVI) has recently developed into an acceptable alternative to conventional surgery in high-risk patients. However, information on the identification of patients gaining most benefit from this procedure is still limited. The aim of this study was to evaluate safety and efficacy of TAVI in different patient cohorts.
methodsBetween August 2008 and December 2010, 180 high-risk patients underwent TAVI at our institution (97 transapical and 83 transfemoral approaches). Periprocedural complications as well as mortality and incidence of MACCE during follow-up were recorded.
resultsMean age was 82 ± 5 years, and mean logistic EuroScore 27 ± 14%. In the total cohort, 30-day mortality was 8.9% and 12-month survival (according to Kaplan-Meier-analysis) 72%, with no significant differences between the two approaches. However, a significant difference in survival was obvious after stratification of patients according to logistic EuroScore mortality estimates. Survival proportions at 1 year were 62% in patients with logistic EuroScore >40%, 71% in patients with EuroScore 20-40% and 80% in octogenarians with EuroScore <20% (P = 0.009). Furthermore, the observed median event-free survival as an indicator for morbidity ranged between 315 days in the first, 442 days in the second and 710 days in the third group (P = 0.1).
conclusionsTAVI proved to be feasible with reproducible results. However, mortality and rehospitalization rates were considerably high in specific patient cohorts, suggesting that the risk-to-benefit ratio of TAVI should be validated individually. In the present study, octogenarians with logistic EuroScore <20% could be identified as candidates apparently gaining high benefit from the procedure.
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