ArticleJournal of gastroenterology2012
Reinfection rate of Helicobacter pylori after eradication treatment: a long-term prospective study in Japan.
Article in Journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02674802 (Reinfection After Eradication of Helicobacter Pylori Infection in Adult), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reinfection After Eradication of Helicobacter Pylori Infection in Adult :A National Multicentre Study
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Guidelines for the management of Helicobacter pylori infection in Japan: 2024 revised edition.Journal of gastroenterology · 2026Guideline
- The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood.Pediatrics international : official journal of the Japan Pediatric Society · 2020Guideline
- Randomised clinical trial: efficacy and safety of vonoprazan vs. lansoprazole in patients with gastric or duodenal ulcers - results from two phase 3, non-inferiority randomised controlled trials.Alimentary pharmacology & therapeutics · 2017Trial
- Evolving landscape of potassium-competitive acid blockers: toward disease-specific use beyond acid suppression.Journal of gastroenterology · 2026Review
- Atypical acuteFujita medical journal · 2026Article
- Current status ofFujita medical journal · 2026Article
- Review
- Epidemiology of dyspepsia and esophagogastroduodenoscopic findings in the era ofWorld journal of gastroenterology · 2025Article
- Article
- Long-term Response of Helicobacter pylori Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study.Journal of epidemiology · 2023Article
- Gut microbiota changes related to Helicobacter pylori eradication with vonoprazan containing triple therapy among adolescents: a prospective multicenter study.Scientific reports · 2021Article
- Endoscopic severe mucosal atrophy indicates the presence of gastric cancer after Helicobacter pylori eradication -analysis based on the Kyoto classification.BMC gastroenterology · 2020Article
- Risk of gastric cancer in the second decade of follow-up after Helicobacter pylori eradication.Journal of gastroenterology · 2020Article
- Long-term follow-up ofEmerging microbes & infections · 2020Observational
- Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps.Nature communications · 2019Article
- Impact of health insurance coverage forBMJ open · 2017Observational
- Low Re-infection Rate of Helicobacter pylori after Successful Eradication in Thailand: A 2 Years StudyAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Novel and Effective Therapeutic Regimens forFrontiers in cellular and infection microbiology · 2017Review
- Pathogenesis and risk factors for gastric cancer after Helicobacter pylori eradication.World journal of gastrointestinal oncology · 2016Review
- Seventeen-year effects of eradicating Helicobacter pylori on the prevention of gastric cancer in patients with peptic ulcer; a prospective cohort study.Journal of gastroenterology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously reported that the reinfection rate with Helicobacter pylori in Japan was low despite a high prevalence of infection. In the present study, we extended our previous work to more accurately determine the reinfection rate.
methodsWe enrolled 1625 patients (219 women and 1406 men, mean age 50.8 years) who had received H. pylori eradication therapy. After documentation of eradication, bacterial culture and urea breath test were carried out yearly. H. pylori strains were analyzed by using random amplification of polymorphic DNA fingerprinting.
resultsA total of 1609 patients were followed for up to 12.5 years (mean 4.7 years); H. pylori became re-positive in 26 patients. In 13 of the 26 patients, H. pylori became positive at the first-year follow up. Stored H. pylori isolates were available for analysis from ten of the 13 patients; four of the isolates were genetically different from the initial strain, but the other six were identical to the initial strain. In the other 13 patients, H. pylori became positive at later follow up (mean 4.8 years; range 1.8-8.0 years). In all of the four of these patients whose isolates could be analyzed, the H. pylori strains were different from the initial strain. Assuming that reinfection occurred in the four patients positive for different strains of H. pylori at the first-year follow up and in the 13 positive at later follow up, the reinfection rate was 0.22% per year.
conclusionsWhen probable recrudescence (H. pylori positivity with identical strains) was excluded, the reinfection rate of H. pylori in this Japanese population was very low, but we note that reinfection can occur over many years.
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