ReviewLangenbeck's archives of surgery2012
Biology and significance of circulating and disseminated tumour cells in colorectal cancer.
Review in Langenbeck's archives of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Review
- Clinical utility of circulating tumor cells: an update.Molecular oncology · 2021Review
- Photoacoustic detection of circulating melanoma cells in late stage patients.Journal of innovative optical health sciences · 2020Article
- Comparative Analysis of Blood and Bone Marrow for the Detection of Circulating and Disseminated Tumor Cells and Their Prognostic and Predictive Value in Esophageal Cancer Patients.Journal of clinical medicine · 2020Article
- Characterization of Stem-like Circulating Tumor Cells in Pancreatic Cancer.Diagnostics (Basel, Switzerland) · 2020Article
- Review
- Article
- Review
- Clinical Potential of Circulating Tumor Cells in Colorectal Cancer: A Prospective Study.Clinical and translational gastroenterology · 2019Article
- Correlation of pulmonary venous circulating tumor cells with clinicopathological parameters in patients with early-stage lung adenocarcinoma.Translational cancer research · 2019Article
- Isolated Metastases to Multiple Genital Organs: a Curious Case of Metachronous Spread of Carcinoma Colon.Indian journal of surgical oncology · 2019Article
- Prognostic models based on postoperative circulating tumor cells can predict poor tumor recurrence-free survival in patients with stage II-III colorectal cancer.Journal of Cancer · 2019Article
- Circulating tumor cells in clinical research and monitoring patients with colorectal cancer.Oncotarget · 2018Review
- Tumor microenvironment promotes prostate cancer cell dissemination via the Akt/mTOR pathway.Oncotarget · 2018Article
- Epidermal growth factor-mediated Rab25 pathway regulates integrin β1 trafficking in colon cancer.Cancer cell international · 2018Article
- Isolation of Circulating Tumor Cells in an Orthotopic Mouse Model of Colorectal Cancer.Journal of visualized experiments : JoVE · 2017Article
- A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer.Journal of visualized experiments : JoVE · 2017Article
- Article
- Does the mobilization of circulating tumour cells during cancer therapy cause metastasis?Nature reviews. Clinical oncology · 2017Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMore than 130 years ago, circulating tumour cells (CTCs) and disseminated tumour cells (DTCs) have been linked to metastasis. Since then, a myriad of studies attempted to characterise and elucidate the clinical impact of CTCs/DTCs, amongst others in colorectal cancer (CRC). Due to a flood of heterogeneous findings regarding CTCs/DTCs in CRC, this review aims to describe the known facts about CTC/DTC biology and clinical impact.
methodsTo identify the basic scientific literature regarding the biology and clinical impact of CTCs/DTCs in CRC, we reviewed the literature in the PubMed database. We focused on publications written in English and published until January 2012. As search terms, we used "colorectal cancer (CRC)", "colon cancer (CC)", "CTC", "DTC", "bone marrow (BM)", "lymph node (LN)", "peripheral blood (PB)", "significance" and "prognosis".
resultsCTC detection and quantification under standardised conditions is feasible. Several studies in large patient settings have revealed prognostic impact of CTCs in CRC. CRC-derived DTC detection and analysis in BM exhibits a more heterogeneous picture but also shows clinical value. Furthermore, the presence of DTCs in LN has a strong prognostic impact in CRC.
conclusionsClinical relevance and prognostic significance of CTCs/DTCs in CRC have been clearly demonstrated in many experimental studies. The major challenge in CTC/DTC research is now to harmonise the various identification and detection approaches and consequently to conduct large prospective multi-institutional trials to verify the use of CTCs/DTCs as a valid prognostic and predictive biomarker for clinical routine.
Indexed as
Identifiers
22350614What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.