ArticleAnnals of surgical oncology2012
Association of type O blood with pancreatic neuroendocrine tumors in Von Hippel-Lindau syndrome.
Article in Annals of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Genetically determined ABO blood group, secretor status, Lewis antigens, and panNEN risk.Endocrine-related cancer · 2026Article
- Inherited syndromes involving pancreatic neuroendocrine tumors.Journal of gastrointestinal oncology · 2020Review
- The utility ofEuropean journal of radiology · 2019Article
- In silico VHL Gene Mutation Analysis and Prognosis of Pancreatic Neuroendocrine Tumors in von Hippel-Lindau Disease.The Journal of clinical endocrinology and metabolism · 2018Article
- Association between ABO blood types and sporadic pancreatic neuroendocrine tumors in the Chinese Han population.Oncotarget · 2017Article
- Blood type biochemistry and human disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Evaluation and management of pancreatic lesions in patients with von Hippel-Lindau disease.Nature reviews. Clinical oncology · 2016Review
- A differential diagnosis of inherited endocrine tumors and their tumor counterparts.Clinics (Sao Paulo, Brazil) · 2013Review
- Association of type-O blood with neuroendocrine tumors in multiple endocrine neoplasia type 1.The Journal of clinical endocrinology and metabolism · 2013Article
- Cystic replacement of pancreas in patient with von hippel-lindau syndrome.Gastrointestinal cancer research : GCR · 2013Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundABO blood type antigens are expressed not only on human red blood cells, but also throughout the gastrointestinal tract and in normal pancreatic tissue. Previous studies have identified an association between ABO blood type and various malignancies. We analyzed the association of ABO blood type with pancreatic neuroendocrine tumors (PNETs) in a high-risk cohort of patients with Von Hippel-Lindau (VHL) syndrome.
methodsA retrospective review was performed of 798 patients with VHL syndrome. Blood type was confirmed for 181 patients. Fisher's exact test and Mehta's modification to Fisher's exact test were used to test for an association between ABO blood type and manifestations of VHL syndrome.
resultsWe found a strong trend for association between O blood type and pancreatic disease manifestation in patients with VHL syndrome (P = 0.047). More importantly, there was a significant association of O blood type with solid pancreatic lesions consistent with PNETs (P = 0.0084). Patients with solid pancreatic lesions who met criteria for surgical resection at the National Institutes of Health also had a higher rate of O blood type than those who did not require surgery (P = 0.051).
conclusionsOur findings suggest an association between O blood type and pancreatic manifestation of disease in patients with VHL syndrome, especially for PNETs. Screening and surveillance approaches for pancreatic lesions in patients with VHL syndrome should also consider patient blood type. The possibility of A, B, H misexpression in PNETs should also be explored to determine whether the serologic association with disease translates into a relationship with tissue pathology.
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