Evidence map›Paper›PMID 22350596›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012

Frequency of depression among oncology outpatients and association with other symptoms.

Wadih Rhondali, Elise Perceau, Julien Berthiller, Pierre Saltel, Veronique Trillet-Lenoir, Olivier Tredan, Jean-Pierre Coulon, Eduardo Bruera, Marilene Filbet

Registry-linked trialAbstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02783430 (Evaluation of the Initial Prescription of Ketamine and Milnacipran Forin Depression in Patients With a Progressive Disease), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02783430 phase2 / phase3completednot on this mapstarted 2016, after this paper: background citation

Evaluation of the Initial Prescription of Ketamine and Milnacipran Forin Depression in Patients With a Progressive Disease

TypeinterventionalSponsorUniversity Hospital, LilleRan2016 to 2024Enrolled42ConditionsDepressionArmsKetamine, Milnacipran, Placebo
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Difficult Task of Diagnosing Depression in Elderly People with Cancer: A Systematic Review.Clinical practice and epidemiology in mental health : CP & EMH · 2021
    Pooled it
  2. The Need for Specialized Oncology Training for Clinical Ethicists.HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues · 2024
    Article
  3. Article
  4. Challenges in virtual collection of patient-reported data: a prospective cohort study conducted in COVID-19 era.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Association between supportive care interventions and patient self-reported depression among advanced cancer outpatients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Article
  14. Article
  15. Article
  16. Predictors of anxiety and depression in people with colorectal cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014
    Article
  17. Article
  18. Article
  19. Article
  20. Suicide Screening in the Oncology Population.Journal of the advanced practitioner in oncology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wadih RhondaliDepartment of Palliative Care and Rehabilitation Medicine, Unit 1414, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. wadihrhondali@gmail.com
Elise Perceau
Julien Berthiller
Pierre Saltel
Veronique Trillet-Lenoir
Olivier Tredan
Jean-Pierre Coulon
Eduardo Bruera
Marilene Filbet

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDepression occurs among an estimated 15% of cancer patients (range, 1-77.5%). Our main objective was to identify the frequency of reported depression by using the Brief Edinburgh Depression Scale (BEDS) among cancer outpatients. Our secondary objective was to identify associated symptoms of cancer using the Edmonton Symptom Assessment System (ESAS) and to evaluate the screening performance of depression between ESAS and BEDS.

methodsIn this multicenter prospective study conducted, we used the ESAS to collect information on nine symptoms: pain, fatigue, nausea, depression, anxiety, drowsiness, shortness of breath, lack of appetite, and feeling of well-being (each rated from 0 to 10). The BEDS was used to assess for "probable depression" (score >6). Data were analyzed using a parametric and nonparametric test.

resultsA total of 146 patients completed the study. The prevalence of probable depression was 43/146 (29%). Probable depression was associated with increased fatigue (p = 0.008), depression (p < 0.0001), anxiety (p < 0.0001), shortness of breath (p = 0.01), and decreased feeling of well-being (p < 0.001). Among patients with probable depression, 42 (98%) patients were not using antidepressants. Regarding the sensitivity and the specificity, we determined that the optimal cutoff for using the ESAS as a depression screening tool was ≥ 2.

conclusionWe found significant associations between probable depression as determined with the BEDS and five symptoms as detected with the ESAS. The vast majority of patients with probable depression were not receiving pharmacological treatment. Depression should be suspected in patients with higher symptom distress as for any one of these 5 ESAS items.

Indexed as

AdultAgedAged, 80 and overAntidepressive AgentsAnxietyDepressionDyspneaFatigueFemaleHumansMaleMass ScreeningMiddle AgedNeoplasmsOutpatientsProspective StudiesAntidepressive Agents

Identifiers

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.