ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2012
Health-related quality of life anticipated with different management strategies for febrile neutropenia in adult cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Ambulatory management of low-risk febrile neutropenia in adult oncological patients. Systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Willingness-to-pay for cancer treatment and outcome: a systematic review.The European journal of health economics : HEPAC : health economics in prevention and care · 2022Pooled it
- Meta-ethnography of experiences of early discharge, with a focus on paediatric febrile neutropenia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Pooled it
- Clinical and cost-effectiveness, safety and acceptability ofBMJ open · 2017Pooled it
- Systematic review of reduced therapy regimens for children with low risk febrile neutropenia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Pooled it
- Febrile neutropenia in patients treated with chemotherapy/immune checkpoint inhibition: a MASCC consensus statement.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Potential reduction of hospital stay length with outpatient management of low-risk febrile neutropenia in a regional cancer center.Cancer reports (Hoboken, N.J.) · 2021Article
- Outpatient management without initial assessment for febrile patients undergoing adjuvant chemotherapy for breast cancer.Molecular and clinical oncology · 2016Article
- ReCAP: Hospitalizations in Older Adults With Advanced Cancer: The Role of Chemotherapy.Journal of oncology practice · 2016Article
- Patient-reported preferences for oral versus intravenous administration for the treatment of cancer: a review of the literature.Patient preference and adherence · 2016Review
- Preference for pharmaceutical formulation and treatment process attributes.Patient preference and adherence · 2016Review
- Health state utilities associated with attributes of treatments for hepatitis C.The European journal of health economics : HEPAC : health economics in prevention and care · 2015Article
- Protocol for a systematic review of reductions in therapy for children with low-risk febrile neutropenia.Systematic reviews · 2014Article
- Management of breast cancer patients with chemotherapy-induced neutropenia or febrile neutropenia.Breast care (Basel, Switzerland) · 2014Review
- The Multinational Association for Supportive Care in Cancer (MASCC) risk index score: 10 years of use for identifying low-risk febrile neutropenic cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Review
- Utilities associated with subcutaneous injections and intravenous infusions for treatment of patients with bone metastases.Patient preference and adherence · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe anticipated health-related quality of life (HRQL) for different hypothetical strategies of febrile neutropenia (FN) management in adult cancer patients.
methodsSeventy-eight adult cancer patients were enrolled. Our study considered four different hypothetical treatment strategies for FN: (1) entire inpatient management with intravenous (IV) antibiotics; (2) oral treatment at home after an initial observation in hospital with IV antibiotics; (3) entire outpatient management with IV antibiotics; and (4) entire outpatient management with oral antibiotics. Initially, patients were asked to rank the different treatment strategies for FN based on their personal preference. Subsequently, HRQL was rated using visual analog scale (VAS), time trade-off (TTO), and willingness-to-pay (WTP).
resultsSeventy-five percent of all respondents preferred an outpatient strategy for FN (36% oral, 21% intravenous, 18% early discharge). Further, outpatient strategies were associated with higher mean VAS scores (possible range 0-10) (oral: 6.1 (standard deviation (SD) 3.1); intravenous: 6.2 (SD 2.2); early discharge: 5.7 (SD 2.1)) as compared to inpatient care (5.3 (SD 2.9)). On the aggregate level, patients were willing to give up between 9 and 10 weeks of their life (TTO; corresponding to <1% of remaining life expectancy) and to pay between $255 and $327 Canadian dollars (WTP) to avoid treatment in hospital.
conclusionsOur study indicates that the majority of adult cancer patients would prefer an outpatient strategy for FN. However, patients' preferences vary substantially at the individual level. Implementation of outpatient strategies into routine clinical practice should consider this variability.
Indexed as
Identifiers
22350594What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.