ArticleNeurochemical research2012
Plasma membrane-associated glycohydrolases along differentiation of murine neural stem cells.
Article in Neurochemical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Hereditary spastic paraparesis type 46 (SPG46): new GBA2 variants in a large Italian case series and review of the literature.Neurogenetics · 2024Review
- Isolation and Culture of Neural Stem/Progenitor Cells from the Postnatal Periventricular Region.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Sphingolipids and plasma membrane hydrolases in human primary bronchial cells during differentiation and their altered patterns in cystic fibrosis.Glycoconjugate journal · 2020Article
- Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease.Molecular neurodegeneration · 2019Article
- Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.The Journal of biological chemistry · 2019Article
- A lysosome-plasma membrane-sphingolipid axis linking lysosomal storage to cell growth arrest.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Evidence for the Involvement of Lipid Rafts and Plasma Membrane Sphingolipid Hydrolases inMediators of inflammation · 2017Article
- The Enigmatic Role of GBA2 in Controlling Locomotor Function.Frontiers in molecular neuroscience · 2017Review
- Identification of "sarsasapogenin-aglyconed" timosaponins as novel Aβ-lowering modulators of amyloid precursor protein processing.Chemical science · 2016Article
- Lipid rafts in neurodegeneration and neuroprotection.Molecular neurobiology · 2014Review
- The glycosphingolipid hydrolases in the central nervous system.Molecular neurobiology · 2014Review
- Mutations in GBA2 cause autosomal-recessive cerebellar ataxia with spasticity.American journal of human genetics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The activities of plasma membrane associated sialidase Neu3, total β-glucosidase, CBE-sensitive β-glucosidase, non-lysosomal β-glucosyl ceramidase GBA2, β-galactosidase, β-hexosaminidase and sphingomyelinase were determined at three different stages of differentiation of murine neural stem cell cultures, corresponding to precursors, commited progenitors, and differentiated cells. Cell immunostaining for specific markers of the differentiation process, performed after 7 days in culture in presence of differentiating agents, clearly showed the presence of oligodendrocytes, astrocytes and neurons. Glial cells were the most abundant. Sialidase Neu3 after a decrease from progenitors to precursors, showed an increase parallel to the differentiation process. All the other glycosidases increased their activity along differentiation. The activity of CBE-sensitive β-glucosidase and GBA2 were very similar at the precursor stage, but CBE-sensitive β-glucosidase increased 7 times while GBA2 only two in the differentiated cells. In addition, we analysed also sphingomyelinase as enzyme specifically associated to sphingolipids. The activity of this enzyme increased from precursors to differentiated cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.