Evidence map›Paper›PMID 22350336›Full record

ArticleJournal of autism and developmental disorders2012

The Study to Explore Early Development (SEED): a multisite epidemiologic study of autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) network.

Diana E Schendel, Carolyn Diguiseppi, Lisa A Croen, M Daniele Fallin, Philip L Reed, Laura A Schieve, Lisa D Wiggins, Julie Daniels, Judith Grether, Susan E Levy and 34 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of autism and developmental disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Longitudinal Examination of Wandering in Children and Adolescents With Autism.Autism : the international journal of research and practice · 2026
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Diana E SchendelNational Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. dschendel@cdc.gov
Carolyn Diguiseppi
Lisa A Croen
M Daniele Fallin
Philip L Reed
Laura A Schieve
Lisa D Wiggins
Julie Daniels
Judith Grether
Susan E Levy
Lisa Miller
Craig Newschaffer
Jennifer Pinto-Martin
Cordelia Robinson
Gayle C Windham
Aimee Alexander
Arthur S Aylsworth
Pilar Bernal
Joseph D Bonner
Lisa Blaskey
Chyrise Bradley
Jack Collins
Casara J Ferretti
Homayoon Farzadegan
Ellen Giarelli
Marques Harvey
Susan Hepburn
Matthew Herr
Kristina Kaparich
Rebecca Landa
Li-Ching Lee
Brooke Levenseller
Stacey Meyerer
Mohammad H Rahbar
Andria Ratchford
Ann Reynolds
Steven Rosenberg
Julie Rusyniak
Stuart K Shapira
Karen Smith
Margaret Souders
Patrick Aaron Thompson
Lisa Young
Marshalyn Yeargin-Allsopp

Funding

Centers for Autism & Develop Disabilities Resarch & Epidemiol:A Case-Cohort StudyU10DD000183 · DD · JOHNS HOPKINS UNIVERSITY · PI FALLIN, M DANIELE · 2006 to 2010
$8.2M
National CADDRE Study: Child Development and AutismU10DD000182 · DD · UNIVERSITY OF PENNSYLVANIA · PI PINTO-MARTIN, JENNIFER A · 2006 to 2010
$5.8M
National CADDRE Study: Child Development and AutismU10DD000181 · DD · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2006 to 2010
$5.6M
Colorado CADDRE: A Case-Cohort StudyU10DD000180 · DD · COLORADO STATE DEPT/PUB HLTH & ENVIRONMT · PI MILLER, LISA ANN · 2006 to 2010
$5.1M
North Carolina Ctr for Autism & Development Disabilities Research & EpidemiologyU10DD000184 · DD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DANIELS, JULIE L · 2006 to 2010
$4.7M
Component A: CADDRE: Study to Explore Early Development (SEED) 3U01DD001210 · DD · UNIVERSITY OF COLORADO DENVER · PI ROBINSON, CORDELIA · 2016 to 2020
$3.8M
Data Coordinating Center for Autism & Other DisabilitiesU01DD000498 · DD · MICHIGAN STATE UNIVERSITY · PI REED, PHILIP L · 2009 to 2011
$2.3M
Intramural CDC HHS CC999999NCBDD CDC HHS U01 DD001210NCBDD CDC HHS U10DD000180NCBDD CDC HHS U10DD000181NCBDD CDC HHS U10DD000182NCBDD CDC HHS U10DD000183NCBDD CDC HHS U10DD000184NCBDD CDC HHS U10DD000498
6 · The paper itself

Abstract

The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal, gastrointestinal, and sociodemographic characteristics. SEED uses a case-control design with population-based ascertainment of children aged 2-5 years with an autism spectrum disorder (ASD) and children in two control groups-one from the general population and one with non-ASD developmental problems. Data from parent-completed questionnaires, interviews, clinical evaluations, biospecimen sampling, and medical record abstraction focus on the prenatal and early postnatal periods. SEED is a valuable resource for testing hypotheses regarding ASD characteristics and causes.

Indexed as

Autistic DisorderCase-Control StudiesChild, PreschoolDevelopmental DisabilitiesFemaleHumansMaleParentsPhenotypePrevalenceSurveys and Questionnaires

Identifiers

PMID22350336
PMCPMC4455890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.