Evidence map›Paper›PMID 22350310›Full record

ArticleOncotarget2012

MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia.

Rosa Visone, Angelo Veronese, Veronica Balatti, Carlo M Croce

Open access · hybridAbstract read
In one paragraph

Article in Oncotarget, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Role of microRNAs in Chronic Lymphocytic Leukemia.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
  5. Review
  6. Enhanced Expression ofCancers · 2021
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
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  16. Review
  17. Article
  18. Review
  19. Article
  20. Down-regulation of miR-181b promotes apoptosis by targeting CYLD in thyroid papillary cancer.International journal of clinical and experimental pathology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rosa VisoneDepartment of Oncology and Experimental Medicine, G. d'Annunzio University, 66100, Chieti, Italy.
Angelo Veronese
Veronica Balatti
Carlo M Croce
The Ohio State University · USUniversity of Chieti-Pescara · IT

Funding

Tissue CoreP01CA081534 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KIPPS, THOMAS J · 2000 to 2016
$59.5M
The Role of Epigenetic Factors in Regulation of Coding and Non-Coding HOX GenesP01CA129242 · NCI · OHIO STATE UNIVERSITY · PI ALDER, HANSJUERG · 2009 to 2013
$4.7M
NCI NIH HHS P01 CA081534NCI NIH HHS P01 CA129242
6 · The paper itself

Abstract

Over the past decades numerous markers of the tumor burden have been discovered in chronic lymphocytic leukemia (CLL). Among these, the microRNAs seem to have a promising role. The development and validation of miRNAs as biomarkers should have significant impact in improving early cancer detection and diagnosis, enhancing therapeutic success, and increasing the life expectancy of patients. We identified miR-181b as a biomarker for the progression of this disease from indolent to aggressive. For this study we used sequential samples from patients with either progressive or stable course of the illness. Here, we discuss more extensively this issue by adding novel findings and introducing a novel approach for monitoring CLL patients.

Indexed as

Biomarkers, TumorB-LymphocytesDisease ProgressionGene Expression Regulation, LeukemicHumansLeukemia, Lymphocytic, Chronic, B-CellMicroRNAsPrognosisBiomarkers, TumorMicroRNAsMIrn181 microRNA, human

Identifiers

PMID22350310
PMCPMC3326649
OpenAlexW2120183470

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.