ArticleJournal of natural medicines2012
Citronellol, a monoterpene alcohol, reduces nociceptive and inflammatory activities in rodents.
Article in Journal of natural medicines, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 114 citations in OpenAlex.
- Antinociceptive Effects of Free and β-Cyclodextrin-Associated α-Phellandrene in CFA-Induced Inflammatory Pain.Biomedicines · 2026Article
- Anti-Inflammatory Effects of Pingyin Rose Essential Oil in LPS-Induced HaCaT Cells: An in Vitro and in Silico Study.International journal of molecular sciences · 2026Article
- Intermolecular Cyclization of Alkyl Chains of Ketones for ConstructingJournal of the American Chemical Society · 2026Article
- Monoterpenes in Vascular Function: A Review of Bioactivity and Mechanisms of Action.International journal of molecular sciences · 2025Review
- Inhibitory action of citronellol on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in juvenile mice.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025Article
- Antioxidant Potential and Oxidative Stress Modulation ofPharmaceuticals (Basel, Switzerland) · 2025Article
- The anti-nociceptive and anti-inflammatory effects of Pelargonium graveolens essential oil nanoemulsion in mice.Scientific reports · 2025Article
- Citronellol protects renal function by exerting anti-inflammatory and antiapoptotic effects against acute kidney injury induced by folic acid in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Ethnobotany and phytochemistry of plants used to treat musculoskeletal disorders among Skaw Karen, Thailand.Pharmaceutical biology · 2024Article
- β-Citronellol: a potential anti-inflammatory and gastro-protective agent-mechanistic insights into its modulatory effects on COX-II, 5-LOX, eNOS, and ICAM-1 pathways through in vitro, in vivo, in silico, and network pharmacology studies.Inflammopharmacology · 2024Article
- Enhancing collagen based nanoemulgel for effective topical delivery of Aceclofenac and Citronellol oil: Formulation, optimization, in-vitro evaluation, and in-vivo osteoarthritis study with a focus on HMGB-1/RAGE/NF-κB pathway, Klotho, and miR-499a.Drug delivery and translational research · 2024Article
- Nigella sativa L. and its bioactive and nutraceutical components in the management of diabetic peripheral neuropathy.Inflammopharmacology · 2024Review
- Rosa × damascena Herrm. From Azaran region, Kashan: rich in saturated and unsaturated fatty acids with inhibitory effect against Proteus mirabilis.BMC complementary medicine and therapies · 2024Article
- Protective effects ofFrontiers in toxicology · 2024Article
- Mechanistic Evaluation of Antiarthritic Effects of Citronellol in CFA-Induced Arthritic Rats.ACS omega · 2023Article
- The Protective Effect of Citronellol against Doxorubicin-Induced Cardiotoxicity in Rats.Biomedicines · 2023Article
- Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in anHeliyon · 2022Article
- Pingyin rose essential oil alleviates LPS-Induced inflammation in RAW 264.7 cells via the NF-κB pathway: an integrated in vitro and network pharmacology analysis.BMC complementary medicine and therapies · 2022Article
- Nitrogen-Containing Heterocyclic Compounds Obtained from Monoterpenes or Their Derivatives: Synthesis and Properties.Topics in current chemistry (Cham) · 2022Review
- Anti-inflammatory and analgesic properties of Moroccan medicinal plants: Phytochemistry,Journal of pharmaceutical analysis · 2022Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the antinociceptive and anti-inflammatory properties of citronellol (CT) in rodents. CT, a monoterpene alcohol, is a naturally occurring monoterpene compound prevalent in essential oils of various aromatic plant species, such as Cymbopogon citratus. In mice, when evaluated against acetic-acid-induced abdominal writhing, CT (25, 50 and 100 mg/kg, i.p.) reduced (P < 0.001) the amount of writhing compared to the control group. In the formalin test, CT also significantly inhibited both the early (neurogenic pain) and the late (inflammatory pain) phases of formalin-induced licking (P < 0.001). When assessed in a thermal model of pain, CT (100 mg/kg, i.p.) caused a significant increase (P < 0.05) in the latency response on the hot-plate test. Such results were unlikely to be caused by motor abnormality. The anti-inflammatory activity of CT was investigated through carrageenan-induced pleurisy in mice. Pretreatment with CT was able to inhibit both neutrophil infiltration and the increase in TNF-α level in the exudates from carrageenan-induced pleurisy. In in vitro experiments, CT (1 and 100 μg/ml) also decreased nitric oxide production by LPS-stimulated macrophage. Together, these results indicate that CT is effective as an analgesic compound in various pain models, with its action probably mediated by the inhibition of peripheral mediators as well as central inhibitory mechanisms that could be related to its strong antioxidant effect observed in vitro.
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Registered trials
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