ArticleMolecular biology reports2012
A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population.
Article in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.PloS one · 2012Pooled it
- Predisposition of the CommonGenes · 2023Article
- The Role of Dietary Glycemic Index and Glycemic Load in Mediating Genetic Susceptibility via MC4R s17782313 Genotypes to Affect Cardiometabolic Risk Factors among Apparently Healthy Obese Individuals.BioMed research international · 2022Article
- The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity.Molecular medicine (Cambridge, Mass.) · 2020Article
- Article
- Dietary quality indices modifies the effects of melanocortin-4 receptor (MC4R) rs17782313 polymorphism on cardio-metabolic risk factors and hypothalamic hormones in obese adults.BMC cardiovascular disorders · 2020Article
- Searching for Factors Raising the Incidence of Metabolic Syndrome Among 45-60-Year-Old Women.Aging and disease · 2018Article
- Prediction of Blood Lipid Phenotypes Using Obesity-Related Genetic Polymorphisms and Lifestyle Data in Subjects with Excessive Body Weight.International journal of genomics · 2018Article
- Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of theClinical interventions in aging · 2017Article
- Article
- Evaluation of the Obesity Genes FTO and MC4R for Contribution to the Risk of Large Artery Atherosclerotic Stroke in a Chinese Population.Obesity facts · 2016Article
- Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort.Endocrine · 2015Article
- Obesity and genomics: role of technology in unraveling the complex genetic architecture of obesity.Human genetics · 2015Review
- A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study.Endocrine · 2014Article
- Obesity-related genomic loci are associated with type 2 diabetes in a Han Chinese population.PloS one · 2014Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A number of recent genome-wide association studies in European populations have reported that variant rs17782313 is significantly associated with obesity and body mass index (BMI). The purpose of the present study was to evaluate the association of rs17782313 with obesity and BMI in the Chinese Han population. We also sought to extend previous studies by determining whether this SNP is associated with plasma lipid levels in the Chinese Han population. Rs17782313 was genotyped in two independent Chinese Han cohorts (Cohort1: n = 2533; Cohort2: n = 2105). In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001). Our findings indicate that the variant rs17782313 near MC4R is likely to have an impact on plasma lipid levels of LDL-C and TC in the Chinese Han population.
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