ArticlePediatric surgery international2012
Bladder augmentation using acellular collagen biomatrix: a pilot experience in exstrophic patients.
Article in Pediatric surgery international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Current evidence regarding alternative techniques for enterocystoplasty using regenerative medicine methods: a systematic review.European journal of medical research · 2024Pooled it
- Review of clinical experience on biomaterials and tissue engineering of urinary bladder.World journal of urology · 2020Pooled it
- Xenogeneic-free platform for the isolation and scalable expansion of human bladder smooth muscle cells.Biotechnology reports (Amsterdam, Netherlands) · 2025Article
- Cell-free biodegradable electroactive scaffold for urinary bladder tissue regeneration.Nature communications · 2025Article
- [Application and progress of bio-derived materials in bladder regeneration and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Assessing the effects of bladder decellularization protocols on extracellular matrix (ECM) structure, mechanics, and biology.Journal of pediatric urology · 2024Article
- Small intestinal submucosa promotes angiogenesis via the Hippo pathway to improve vaginal repair.Biomolecules & biomedicine · 2023Article
- Engineering pedicled vascularized bladder tissue for functional bladder defect repair.Bioengineering & translational medicine · 2023Article
- Urinary Bladder Patch Made with Decellularized Vein Scaffold Seeded with Adipose-Derived Mesenchymal Stem Cells: Model in Rabbits.Biomedicines · 2022Article
- Tissue Engineering and Regenerative Medicine in Pediatric Urology: Urethral and Urinary Bladder Reconstruction.International journal of molecular sciences · 2022Review
- Development of a porcine acellular bladder matrix for tissue-engineered bladder reconstruction.Pediatric surgery international · 2022Article
- Porcine Small Intestinal Submucosa (SIS) as a Suitable Scaffold for the Creation of a Tissue-Engineered Urinary Conduit: Decellularization, Biomechanical and Biocompatibility Characterization Using New Approaches.International journal of molecular sciences · 2022Article
- The Significance of Biomechanics and Scaffold Structure for Bladder Tissue Engineering.International journal of molecular sciences · 2021Review
- Procyanidins-crosslinked small intestine submucosa: A bladder patch promotes smooth muscle regeneration and bladder function restoration in a rabbit model.Bioactive materials · 2021Article
- Current Applications and Future Directions of Bioengineering Approaches for Bladder Augmentation and Reconstruction.Frontiers in surgery · 2021Review
- Long-term follow-up of neurogenic bladder patients after bladder augmentation with small intestinal submucosa.World journal of urology · 2020Article
- Electrospinning: Application and Prospects for Urologic Tissue Engineering.Frontiers in bioengineering and biotechnology · 2020Review
- Innervation: the missing link for biofabricated tissues and organs.NPJ Regenerative medicine · 2020Review
- Tissue Engineering in Pediatric Bladder Reconstruction-The Road to Success.Frontiers in pediatrics · 2019Review
- Bioengineering Approaches for Bladder Regeneration.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA preliminary experience on in vivo bladder wall regeneration in a subset of patients born with exstrophy-epispadias complex is reported. The objective was to improve bladder capacity and compliance without bowel augmentation.
methodsFive patients (3 males, 2 females), mean age 10.4 years, presenting poor bladder capacity and compliance after complete exstrophy repair, underwent bladder augmentation using small intestinal submucosa (SIS) scaffold. Ultrasonography, cystoscopy with cystogram, assessment of bladder volume and compliance and bladder biopsy were performed before surgery (T0), at 6 (T1) and 18 months (T2) follow-up. Histology was compared with normal bladder specimens. Wilcoxon test was adopted for statistics.
resultsBladder capacity and compliance resulted increased (+30%) at T1 (p < 0.05) and remained stable at T2, despite dry intervals did not changed significantly. Bladder biopsy at T1 showed no evidence of SIS, but normal transitional mucosa and sero-muscular layer containing smooth muscle fascicles, small nerve trunks and vessels within abundant type-3 collagen. Muscle/collagen ratio was decreased compared with controls at T1 and T2 (p < 0.05). No kidney damage, bladder diverticula, or stones were observed at 3 years follow-up.
conclusionsBladder regeneration was feasible in these patients, but bladder capacity and compliance was poorly increased to obtain significant clinical benefit. Histology showed poor muscle components. The acellular matrix grafting failed to provide long-term effective results in terms of continence achievement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.