ArticleCell and tissue banking2013
Differential cross-linking and radio-protective effects of genipin on mature bovine and human patella tendons.
Article in Cell and tissue banking, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Exogenous Crosslinking of Tendons as a Strategy for Mechanical Augmentation and Repair: A Narrative Review.Orthopedic research and reviews · 2023Review
- Effects of polycationic drug carriers on the electromechanical and swelling properties of cartilage.Biophysical journal · 2022Article
- Effects of bone types, particle sizes, and gamma irradiation doses in feline demineralized freeze-dried bone allograft.Veterinary world · 2020Article
- Article
- [Progress of sterilization and preservation methods for allografts in anterior cruciate ligament reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2019Review
- Does a different dose of gamma irradiation have the same effect on five different types of tendon allografts? - a biomechanical study.International orthopaedics · 2017Article
- Tendon Collagen Crosslinking Offers Potential to Improve Suture Pullout in Rotator Cuff Repair: An Ex Vivo Sheep Study.Clinical orthopaedics and related research · 2016Article
- Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure-function relationships.Journal of biomechanics · 2016Article
- Regeneration of skeletal system with genipin crosslinked biomaterials.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Gamma irradiation is a proven sterilization method, but is not widely used on allografts for anterior cruciate ligament reconstruction (e.g., patella tendon) due to radiation-induced decreases in mechanical strength. Addressing this drawback would improve the safety and supply of allografts to meet current and future demand. It was hypothesized that genipin-induced collagen cross-linking would increase the tensile modulus of patella tendon tissue such that 5 MRad gamma irradiation would not reduce the tissue mechanical strength below the original untreated values. Optimized genipin treatment increased the tensile modulus of bovine tendons by ~2.4-fold. After irradiation, genipin treated tissue did not significantly differ from native tissue, proving the hypothesis. Optimized genipin treatment of human tendons increased the tensile modulus by ~1.3-fold. After irradiation, both control and genipin-treated tissues possessed ~50-60% of their native tendon modulus, disproving the hypothesis. These results highlight possible age- and species- dependent effects of genipin cross-linking on tendon tissue. Cross-linking of human allografts may be beneficial only in younger donor tissues. Future research is warranted to better understand the mechanisms and applications of collagen cross-linking for clinical use.
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