Evidence map›Paper›PMID 22350010›Full record

ReviewJournal of bioenergetics and biomembranes2012

Transferring knowledge towards understanding the pore stabilizing variations in K(+) channels: pore stability in K(+) channels.

Mobeen Raja, Nick K Olrichs, Elisabeth Vales, Hildgund Schrempf

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of bioenergetics and biomembranes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mobeen RajaSchool of Molecular and Systems Medicine, Alberta Diabetes Institute, University of Alberta, 6126 HRIF East, Edmonton AB T6G 2E1, Canada. mraja@pmcol.ualberta.ca
Nick K Olrichs
Elisabeth Vales
Hildgund Schrempf

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in structural biology underlying mechanisms of channel gating have strengthened our knowledge about how K(+) channels can be inter-convertible between conductive and non-conductive states. We have reviewed and combined mutagenesis with biochemical, biophysical and structural information in order to understand the critical roles of the pore residues in stabilizing the pore structure and channel open state. We also discuss how the latest knowledge on the K(+) channel KcsA may provide a step towards better understanding of distinct pore stabilizing differences among diversified K(+) channels.

Indexed as

Models, MolecularProtein StabilityAmino Acid SequenceBacterial ProteinsIon Channel GatingMolecular Sequence DataMutagenesisPotassium Channels, Voltage-GatedSpecies SpecificityBacterial ProteinsKcsA protein, Streptomyces coelicolorPotassium Channels, Voltage-Gated

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.