ArticleJournal of neurology2012
Pain processing in patients with migraine: an event-related fMRI study during trigeminal nociceptive stimulation.
Article in Journal of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 127 citations in OpenAlex.
- Brain Responses to Noxious Stimuli in Patients With Chronic Pain: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Grey matter alterations in migraine: A systematic review and meta-analysis.NeuroImage. Clinical · 2017Pooled it
- Increased activation of the pregenual anterior cingulate cortex to citalopram challenge in migraine: an fMRI study.BMC neurology · 2019Trial
- Topiramate modulates habituation in migraine: evidences from nociceptive responses elicited by laser evoked potentials.The journal of headache and pain · 2013Trial
- Abnormal Brain Structure and Function in People with Shoulder Pain: A Systematic Review of Neuroimaging Studies.Journal of pain research · 2026Review
- Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study.Frontiers in immunology · 2026Article
- Extracranial Hemodynamic Responses to a Noxious Cold Pressor Task Differ Between Persistent Post-Traumatic Headache and Healthy Controls.Journal of personalized medicine · 2025Article
- Regional and whole-brain neurofunctional alterations during pain empathic processing of physical but not affective pain in migraine patients.The journal of headache and pain · 2025Article
- Neuromodulation for Headache Management in Pregnancy.Current pain and headache reports · 2025Review
- Altered brainstem-cortex activation and interaction in migraine patients: somatosensory evoked EEG responses with machine learning.The journal of headache and pain · 2024Article
- Perfusion imaging by arterial spin labeling in migraine: A literature review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- Article
- Aberrant functional connectivity in anterior cingulate gyrus subregions in migraine without aura patients.Frontiers in neurology · 2024Article
- Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders.The journal of headache and pain · 2023Observational
- Migraine Type-Dependent Patterns of Brain Activation After Facial and Intranasal Trigeminal Stimulation.Brain topography · 2023Article
- Article
- Insular functional connectivity in migraine with aura.The journal of headache and pain · 2022Article
- Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study.The journal of headache and pain · 2022Article
- Dynamic brainstem and somatosensory cortical excitability during migraine cycles.The journal of headache and pain · 2022Article
- The value of brain MRI functional connectivity data in a machine learning classifier for distinguishing migraine from persistent post-traumatic headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We explored the functional pattern of the pain-processing network in patients with migraine, in the interictal periods, during trigeminal noxious stimulation. Contact heat evoked potential stimulation induced thermal pain and functional magnetic resonance imaging were used to measure whole-brain activation in 16 patients with episodic migraine without aura and 16 age- and gender-matched healthy controls in response to a severe (53°C) noxious, a moderate (51°C) noxious, and a control (41°C) stimulus applied to the maxillary skin. When comparing the fMRI activation over the entire brain, patients with migraine, with respect to healthy controls, showed a significantly greater activation in the perigenual part of anterior cingulate cortex at 51°C and less activation in the bilateral secondary somatosensory cortex at 53°C. A group-by-stimulus interaction analysis revealed a region in the pons showing a divergent response in patients and healthy controls. Correlation analyses demonstrated that the pons activation correlated with higher headache-related disability in patients. Our findings demonstrate increased antinociceptive activity in patients with migraine, which may represent a compensatory reorganization to modulate pain perception at the same intensity of healthy controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.