ReviewJournal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology2012
Spinal manipulative therapy and somatosensory activation.
Review in Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Lumbosacral Manipulation on Isokinetic Strength of the Knee Extensors and Flexors
Motor Performance of Asymptomatic and Chronic Neck Pain Participants Pre- and Post-spinal Manipulation Using an Eye and Head Movement Fitts' Task
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- The effects of physiotherapy on neck pain with associated symptoms, ıncludıng cervicogenic dizziness and tinnitus: a systematic review.BMC musculoskeletal disorders · 2026Pooled it
- The effects of spinal manipulative therapy on lower limb neurodynamic test outcomes in adults: a systematic review.The Journal of manual & manipulative therapy · 2020Pooled it
- The impact of spinal manipulation on lumbar proprioception and its link to pain relief: a randomized controlled trial.Scientific reports · 2025Trial
- Efficacy of different biomechanical strategies for modulating force-time parameters of high-velocity low-amplitude manipulation of the thoracic spine: a randomized crossover experimental study.Chiropractic & manual therapies · 2025Trial
- Effects of chiropractic spinal manipulation on laser-evoked pain and brain activity.The journal of physiological sciences : JPS · 2021Trial
- Immediate impact of extremity manipulation on dual task performance: a randomized, crossover clinical trial.Chiropractic & manual therapies · 2021Trial
- The effect of spinal manipulation on brain neurometabolites in chronic nonspecific low back pain patients: a randomized clinical trial.Irish journal of medical science · 2020Trial
- The effects of a single session of chiropractic care on strength, cortical drive, and spinal excitability in stroke patients.Scientific reports · 2019Trial
- Trial
- Association of lumbar spine stiffness and flexion-relaxation phenomenon with patient-reported outcomes in adults with chronic low back pain - a single-arm clinical trial investigating the effects of thrust spinal manipulation.BMC complementary and alternative medicine · 2017Trial
- Neuromechanical response to spinal manipulation therapy: effects of a constant rate of force application.BMC complementary and alternative medicine · 2016Trial
- Short term modulation of trunk neuromuscular responses following spinal manipulation: a control group study.BMC musculoskeletal disorders · 2013Trial
- Article
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- The pathophysiologic mechanisms of spinal manipulative therapy in the management of chronic musculoskeletal pain.The Journal of the Canadian Chiropractic Association · 2025Article
- The Impact of a Single Hip Manipulation on Quadriceps Activity and Performance: A Randomized Study.Biomedicines · 2025Article
- Neuromuscular Response to High-Velocity, Low-Amplitude Spinal Manipulation-An Overview.Medicina (Kaunas, Lithuania) · 2025Review
- An exploration of trauma-informed care curricula in chiropractic programs: A scoping document analysis protocol.PloS one · 2025Article
- Self-Administered Traction as an Adjunct in the Chiropractic Treatment of Low Back Pain: A Case Report.Journal of chiropractic medicine · 2024Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Manually-applied movement and mobilization of body parts as a healing activity has been used for centuries. A relatively high velocity, low amplitude force applied to the vertebral column with therapeutic intent, referred to as spinal manipulative therapy (SMT), is one such activity. It is most commonly used by chiropractors, but other healthcare practitioners including osteopaths and physiotherapists also perform SMT. The mechanisms responsible for the therapeutic effects of SMT remain unclear. Early theories proposed that the nervous system mediates the effects of SMT. The goal of this article is to briefly update our knowledge regarding several physical characteristics of an applied SMT, and review what is known about the signaling characteristics of sensory neurons innervating the vertebral column in response to spinal manipulation. Based upon the experimental literature, we propose that SMT may produce a sustained change in the synaptic efficacy of central neurons by evoking a high frequency, bursting discharge from several types of dynamically-sensitive, mechanosensitive paraspinal primary afferent neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.