ReviewNature reviews. Nephrology2012
Glomerular hyperfiltration: definitions, mechanisms and clinical implications.
Review in Nature reviews. Nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03629561 (Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias), which is not on this map. Cited by 359 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias
Who cites it
359 citing papers in PubMed, 2 syntheses or guidelines pooled it, 655 citations in OpenAlex.
- Association of glomerular hyperfiltration with mortality in stroke: an analysis using pooled individual patient data.European stroke journal · 2026Pooled it
- Cross-phenotype association analysis of gastric cancer: in-silico functional annotation based on the disease-gene network.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Pooled it
- Urinary clusterin as a biomarker of human kidney disease progression and response to the endothelin receptor antagonist atrasentan: An exploratory analysis from the SONAR trial.Nature communications · 2026Trial
- Heterogeneity in the efficacy of bosentan for hypertensive nephropathy: a study on individualized benefit prediction models based on pathological subtyping and dynamic trajectories.Annals of medicine · 2026Article
- Free-Breathing Arterial Spin Labeling MRI of the Kidney Using Flow-Sensitive-Alternating Inversion Recovery With Golden-Angle Radial Sampling.NMR in biomedicine · 2026Article
- Association of Enlarged Perivascular Spaces and Total Small Vessel Disease Burden With Kidney Function.Neurology · 2026Article
- Renal outcomes and compensatory hypertrophy in survivors of unilateral non-syndromic Wilms tumour: a single-centre cross-sectional study from a tertiary-care institution in India.Pediatric surgery international · 2026Article
- Review
- Estimated glomerular filtration rate discordance and cardiopulmonary morbidity in sickle cell disease.Blood advances · 2026Article
- Prevalence, clinical characteristics and management of low-renin hypertension: a real-world cohort study.Journal of human hypertension · 2026Article
- Factors associated with contralateral renal parenchymal volume changes after partial nephrectomy: A retrospective cohort study.BJUI compass · 2026Article
- Natural History of Chronic Kidney Disease in Sickle Cell Disease.American journal of hematology · 2026Review
- Renal Functional Reserve-Informed Personalized Renoprotection in Chronic Kidney Disease: A Proposed Extension of the KDIGO CGA Framework.Biomedicines · 2026Review
- Contrast-enhanced ultrasound and photoacoustic imaging to assess early and late renal ischemia-reperfusion injuries in male mice.Physiological reports · 2026Article
- Higher Small Dense LDL Cholesterol to LDL Cholesterol Ratio is Associated with Glomerular Hyperfiltration in Adults without Diabetes.Journal of atherosclerosis and thrombosis · 2026Article
- From Metabolic Syndrome to Cardiovascular-Kidney-Metabolic Syndrome (CKM): A Clinical and Pathophysiological Continuum.Biomedicines · 2026Review
- Serum Protein Electrophoresis and the Albumin-to-Globulin Ratio in the Differential Diagnosis of Minimal Change Disease and Focal Segmental Glomerulosclerosis.Biomedicines · 2026Article
- Impact of sotagliflozin on glomerular hyperfiltration in people with type 1 diabetes: A post hoc analysis of the inTandem3 trial.Diabetes, obesity & metabolism · 2026Article
- Hepatorenal vulnerability flagged by glomerular hyperfiltration in metabolic liver disease: a large health-screening cohort evidence.Diabetology & metabolic syndrome · 2026Article
- Proteinuria as an Unusual Presentation of Pheochromocytoma in Pediatric Patient With Single Kidney.Case reports in pediatrics · 2026Article
299 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glomerular hyperfiltration is a phenomenon that can occur in various clinical conditions including kidney disease. No single definition of glomerular hyperfiltration has been agreed upon, and the pathophysiological mechanisms, which are likely to vary with the underlying disease, are not well explored. Glomerular hyperfiltration can be caused by afferent arteriolar vasodilation as seen in patients with diabetes or after a high-protein meal, and/or by efferent arteriolar vasoconstriction owing to activation of the renin-angiotensin-aldosterone system, thus leading to glomerular hypertension. Glomerular hypertrophy and increased glomerular pressure might be both a cause and a consequence of renal injury; understanding the renal adaptations to injury is therefore important to prevent further damage. In this Review, we discuss the current concepts of glomerular hyperfiltration and the renal hemodynamic changes associated with this condition. A physiological state of glomerular hyperfiltration occurs during pregnancy and after consumption of high-protein meals. The various diseases that have been associated with glomerular hyperfiltration, either per nephron or per total kidney, include diabetes mellitus, polycystic kidney disease, secondary focal segmental glomerulosclerosis caused by a reduction in renal mass, sickle cell anemia, high altitude renal syndrome and obesity. A better understanding of the mechanisms involved in glomerular hyperfiltration could enable the development of new strategies to prevent progression of kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.