ArticleClinical neuroradiology2012
Visualisation of the zona incerta for deep brain stimulation at 3.0 Tesla.
Article in Clinical neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Visualization of subthalamic nucleus on susceptibility weighted imaging and the verification of accuracy by microelectrode recording.Frontiers in human neuroscience · 2025Article
- An Updated Overview of the Magnetic Resonance Imaging of Brain Iron in Movement Disorders.Behavioural neurology · 2022Review
- Asleep Deep Brain Stimulation of the Nucleus Ventralis Intermedius for Essential Tremor Using Indirect Targeting and Interventional Magnetic Resonance Imaging: Single-Institution Case Series.Movement disorders clinical practice · 2020Article
- Deep Learning-Based Deep Brain Stimulation Targeting and Clinical Applications.Frontiers in neuroscience · 2019Article
- Contributions to magnetic susceptibility of brain tissue.NMR in biomedicine · 2017Review
- Deep Brain Stimulation of the H Fields of Forel Alleviates Tics in Tourette Syndrome.Frontiers in human neuroscience · 2017Article
- Towards a mechanistic understanding of the human subcortex.Nature reviews. Neuroscience · 2016Review
- Efficient imaging of midbrain nuclei using inverse double-echo steady-state acquisition.Medical physics · 2015Article
- Ultra-high field magnetic resonance imaging of the basal ganglia and related structures.Frontiers in human neuroscience · 2014Article
- Imaging for deep brain stimulation: The zona incerta at 7 Tesla.World journal of radiology · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDeep-brain stimulation (DBS) of the zona incerta (ZI) has shown promising results for medication-refractory neurological disorders including Parkinson's disease (PD) and essential tremor (ET). The success of the intervention is indispensably dependent on the reliable visualisation of the ZI. The aim of the study was to evaluate different promising new magnetic resonance imaging (MRI) methods at 3.0 Tesla for pre-stereotactic visualisation of the ZI using a standard installation the protocol.
methodsMRI of nine healthy volunteers was acquired (T1-MPRAGE, T2-FLAIR, T2*-FLASH2D, T2-SPACE and susceptibility-weighted imaging (SWI). Image quality and visualisation of the ZI for each sequence were analysed independently by two neuroradiologists using a 6-point scale. For T2*-FLASH2D the axial, coronal and sagittal planes were compared. The delineation of the ZI versus the internal capsule, the subthalamic nucleus and the pallidofugal fibres was evaluated in all sequences and compared to T2-FLAIR using a paired t-test. Inter-rater reliability, contrast-to-noise ratios (CNR), and signal-to-noise ratios (SNR) for the ZI were computed. For illustration, coronal T2*-FLASH2D images were co-registered with the corresponding section schema of the Schaltenbrand-Wahren stereotactic atlas.
resultsOnly the rostral part of the ZI (rZI) could be identified. The rZI was best and reliably visualised in T2*-FLASH2D (particularly coronal orientation; p < 0.05). No major artifacts in the rZI were observed in any of the sequences. SWI, T2-SPACE, and T2*-FLASH imaging offered significant higher CNR values for the rZI compared to T2-FLAIR imaging using standard parameters. The co-registration of the coronal T2*-FLASH2D images projected the ZI clearly into the boundaries of the anatomical sections.
conclusionsThe delineation of the rZI is best possible in T2*-FLASH2D (particularly coronal view) using a standard installation protocol at 3.0 T. The caudal ZI could not be discerned in any of the sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.