ArticleCellular and molecular life sciences : CMLS2012
Mesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences.
Article in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed.
- CD9/SOX2-positive cells in the intermediate lobe of the rat pituitary gland exhibit mesenchymal stem cell characteristics.Cell and tissue research · 2025Article
- Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomal miRNA-21-5p Inhibits Lidocaine-Induced Apoptosis in SH-SY5Y Neuroblastoma Cells.Iranian journal of public health · 2023Article
- Promising Markers in the Context of Mesenchymal Stem/Stromal Cells Subpopulations with Unique Properties.Stem cells international · 2023Review
- Mesenchymal Stromal Cell Therapy in Spinal Cord Injury: Mechanisms and Prospects.Frontiers in cellular neuroscience · 2022Review
- Proteasome inhibition-enhanced fracture repair is associated with increased mesenchymal progenitor cells in mice.PloS one · 2022Article
- Harnessing 3D collagen hydrogel-directed conversion of human GMSCs into SCP-like cells to generate functionalized nerve conduits.NPJ Regenerative medicine · 2021Article
- Potential Therapeutic Strategies and Substances for Facial Nerve Regeneration Based on Preclinical Studies.International journal of molecular sciences · 2021Review
- The human bone marrow harbors a CD45Stem cells translational medicine · 2021Article
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- Integrated Analyses of Mouse Stem Cell Transcriptomes Provide Clues for Stem Cell Maintenance and Transdifferentiation.Frontiers in genetics · 2020Article
- Nomenclature and heterogeneity: consequences for the use of mesenchymal stem cells in regenerative medicine.Regenerative medicine · 2019Review
- Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Neural Crest Stem-Like Cells Non-genetically Induced from Human Gingiva-Derived Mesenchymal Stem Cells Promote Facial Nerve Regeneration in Rats.Molecular neurobiology · 2018Article
- Neural crest stem cells protect spinal cord neurons from excitotoxic damage and inhibit glial activation by secretion of brain-derived neurotrophic factor.Cell and tissue research · 2018Article
- Cre-driver lines used for genetic fate mapping of neural crest cells in the mouse: An overview.Genesis (New York, N.Y. : 2000) · 2018Review
- Novel Regenerative Therapies Based on Regionally Induced Multipotent Stem Cells in Post-Stroke Brains: Their Origin, Characterization, and Perspective.Translational stroke research · 2017Review
- Sox10Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Identification of Multipotent Stem Cells in Human Brain Tissue Following Stroke.Stem cells and development · 2017Article
Corrections and comments
- Retraction · 2021-05-08Concerns/Issues about Data · Duplication of/in Image · · see also: https://pubpeer.com/publications/F31F8CADF38E1DF684A26265AEC062
- Retracted
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crest stem cells (NCSC) might explain the neuronal phenotypic plasticity shown by bone marrow cells. However, little information is available about the nature of these cells compared to mesenchymal stem cells (MSC), including their similarities and differences. In this paper, using transcriptomic as well as proteomic technologies, we compared NCSC to MSC and stromal nestin-positive cells, all of them isolated from adult bone marrow. We demonstrated that the nestin-positive cell population, which was the first to be described as able to differentiate into functional neurons, was a mixed population of NCSC and MSC. More interestingly, we demonstrated that MSC shared with NCSC the same ability to truly differentiate into Tuj1-positive cells when co-cultivated with paraformaldehyde-fixed cerebellar granule neurons. Altogether, those results suggest that both NCSC and MSC can be considered as important tools for cellular therapies in order to replace neurons in various neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.